Browse proteases
110 proteases with experimental cleavage evidence across the atlas.
| Protease | Gene / alias | MEROPS | Sources | Substrates | Sites | Example substrates |
|---|---|---|---|---|---|---|
FURIN | FURIN|PCSK2|PCSK4|PCSK5|PCSK6, FURIN|PCSK2|PCSK4|PCSK5|PCSK6|PCSK7, furin and PCSK7, furin like-convertase, furin-like proprotein convertase, furin-like protease | S08.071, S08.071|S08.073|S08.074|S08.075|S08.076, S08.071|S08.073|S08.074|S08.075|S08.076|S08.077 | hprd+merops+pmaphprd+merops+pmap+uniprotmeropsmerops+uniprotuniprot | 45 | 50 | ADAM10 , ADAM12 , ADAM15 , ADAM19 , ADAM8 , ADAM9 , ADGRB2 , ADGRF5 , ADGRG6 , ATP6AP1 , +35 |
MEP1B | MEP1A|MEP1B | M12.002|M12.004, M12.002|M12.004|M12.033, M12.004, M12.004|M12.033 | merops | 30 | 43 | ADAM10 , ADAM15 , ADAM9 , ANKAR , APLP2 , APP , ASPH , CANX , CD99 , CLIC1 , +20 |
MMP2 | F2|MMP2, MMP2|MMP7|MMP9 | M10.003, M10.003|M10.004|M10.008, M10.003|S01.217 | hprd+merops+pmapmerops | 26 | 32 | ADGRG1 , APMAP , APP , CADM1 , CLIC1 , CLIC4 , CSPG4 , EPHB1 , FGFR1 , GRM4 , +16 |
PCSK4 | FURIN|PCSK2|PCSK4|PCSK5|PCSK6, FURIN|PCSK2|PCSK4|PCSK5|PCSK6|PCSK7, PCSK2|PCSK4|PCSK5|PCSK6, PCSK2|PCSK4|PCSK5|PCSK6|PCSK7, PCSK2|PCSK4|PCSK6|PCSK7, PCSK4|PCSK5|PCSK6|PCSK7 | S08.071|S08.073|S08.074|S08.075|S08.076, S08.071|S08.073|S08.074|S08.075|S08.076|S08.077, S08.073|S08.074|S08.075|S08.076, S08.073|S08.074|S08.075|S08.076|S08.077, S08.073|S08.074|S08.075|S08.077, S08.074|S08.075|S08.076|S08.077 | merops | 22 | 23 | ADAM10 , ADAM12 , ADAM17 , ADAM19 , BACE1 , EDA , FURIN , HBEGF , INSR , ITGA2B , +12 |
PCSK5 | FURIN|PCSK2|PCSK4|PCSK5|PCSK6, FURIN|PCSK2|PCSK4|PCSK5|PCSK6|PCSK7, PCSK2|PCSK4|PCSK5|PCSK6, PCSK2|PCSK4|PCSK5|PCSK6|PCSK7, PCSK4|PCSK5|PCSK6|PCSK7 | S08.071|S08.073|S08.074|S08.075|S08.076, S08.071|S08.073|S08.074|S08.075|S08.076|S08.077, S08.073|S08.074|S08.075|S08.076, S08.073|S08.074|S08.075|S08.076|S08.077, S08.074|S08.075|S08.076|S08.077, S08.076 | merops | 22 | 23 | ADAM10 , ADAM12 , ADAM17 , ADAM19 , BACE1 , EDA , FURIN , HBEGF , INSR , ITGA2B , +12 |
PCSK6 | FURIN|PCSK2|PCSK4|PCSK5|PCSK6, FURIN|PCSK2|PCSK4|PCSK5|PCSK6|PCSK7, PCSK2|PCSK4|PCSK5|PCSK6, PCSK2|PCSK4|PCSK5|PCSK6|PCSK7, PCSK2|PCSK4|PCSK6|PCSK7, PCSK4|PCSK5|PCSK6|PCSK7 | S08.071|S08.073|S08.074|S08.075|S08.076, S08.071|S08.073|S08.074|S08.075|S08.076|S08.077, S08.073|S08.074|S08.075|S08.076, S08.073|S08.074|S08.075|S08.076|S08.077, S08.073|S08.074|S08.075|S08.077, S08.074|S08.075|S08.076|S08.077 | merops | 22 | 23 | ADAM10 , ADAM12 , ADAM17 , ADAM19 , BACE1 , EDA , FURIN , HBEGF , INSR , ITGA2B , +12 |
PCSK7 | FURIN|PCSK2|PCSK4|PCSK5|PCSK6|PCSK7, PCSK2|PCSK4|PCSK5|PCSK6|PCSK7, PCSK2|PCSK4|PCSK6|PCSK7, PCSK4|PCSK5|PCSK6|PCSK7, furin and PCSK7 | S08.071|S08.073|S08.074|S08.075|S08.076|S08.077, S08.073|S08.074|S08.075|S08.076|S08.077, S08.073|S08.074|S08.075|S08.077, S08.074|S08.075|S08.076|S08.077, S08.077 | meropsuniprot | 22 | 23 | ADAM10 , ADAM12 , ADAM17 , ADAM19 , BACE1 , EDA , FURIN , HBEGF , INSR , ITGA2B , +12 |
MEP1A | MEP1A|MEP1B | M12.002, M12.002|M12.004, M12.002|M12.004|M12.033 | merops | 21 | 30 | ADAM9 , APP , ASPH , CLIC1 , CLSTN1 , DSC3 , DSG3 , DSG4 , F11R , FAT2 , +11 |
PCSK2 | FURIN|PCSK2|PCSK4|PCSK5|PCSK6, FURIN|PCSK2|PCSK4|PCSK5|PCSK6|PCSK7, PCSK2|PCSK4|PCSK5|PCSK6, PCSK2|PCSK4|PCSK5|PCSK6|PCSK7, PCSK2|PCSK4|PCSK6|PCSK7 | S08.071|S08.073|S08.074|S08.075|S08.076, S08.071|S08.073|S08.074|S08.075|S08.076|S08.077, S08.073, S08.073|S08.074|S08.075|S08.076, S08.073|S08.074|S08.075|S08.076|S08.077, S08.073|S08.074|S08.075|S08.077 | merops | 20 | 21 | ADAM10 , ADAM17 , ADAM19 , BACE1 , EDA , FURIN , HBEGF , INSR , ITGA3 , ITGA4 , +10 |
GZMB | CASP3|GZMB | C14.003|S01.010, S01.010 | hprd+meropsmerops | 18 | 23 | CACNA1C , CHRNA7 , CLIC1 , CLIC2 , CNGA1 , DLL1 , DSG2 , F2R , GRIA3 , GRIA4 , +8 |
ADAM17 | ADAM10 and ADAM17, alpha-secretase | M12.217 | hprd+merops+pmapmeropsmerops+pmapuniprot | 14 | 21 | ACE , APP , AREG , BTC , ERBB4 , EREG , FCGR3A , GP1BA , HBEGF , IL6R , +4 |
KLK4 | — | S01.251 | merops | 12 | 12 | BACE1 , CDH1 , CDH2 , CDH3 , CDH4 , CDH5 , DSG1 , DSG3 , EPCAM , F2RL1 , +2 |
MBTPS1 | — | S08.063 | meropsuniprot | 12 | 13 | ATF6 , ATF6B , CREB3 , CREB3L1 , CREB3L2 , CREB3L3 , CREB3L4 , FAM20C , GNPTAB , MBTPS1 , +2 |
MMP14 | ADAM10|MMP14|MMP17, MMP14|MMP17 | M10.014, M10.014|M10.017, M10.014|M10.017|M12.210 | hprd+meropshprd+merops+pmapmeropsmerops+papermerops+pmapuniprot | 12 | 30 | APP , BCAM , BSG , CD44 , CDH1 , HBEGF , ITGAV , MMP14 , PTK7 , SDC1 , +2 |
MMP7 | MMP2|MMP7|MMP9 | M10.003|M10.004|M10.008, M10.008 | meropsmerops+papermerops+pmap | 12 | 18 | ADAM28 , CDH1 , FAS , FASLG , IGHG1 , IGHG3 , IGHG4 , ITGB4 , MAG , OCLN , +2 |
F2 | CTSG|F2|PLG, F2|MMP2, F2|PLG, thrombin, thrombin and CTSG, thrombin or trypsin | M10.003|S01.217, S01.133|S01.151|S01.217|S01.233, S01.151|S01.217, S01.217, S01.217|S01.233 | hprd+meropsmeropsmerops+pmapuniprot | 10 | 13 | ADGRA2 , C9 , CLIC1 , F2R , F2RL1 , F2RL2 , F2RL3 , GP5 , SDC4 , SLC10A4 |
PLG | CTSG|F2|PLG, F2|PLG | S01.133|S01.151|S01.217|S01.233, S01.151, S01.217|S01.233, S01.233 | hprd+meropshprd+merops+pmapmeropsmerops+pmap | 10 | 17 | APP , F2R , F2RL1 , F2RL3 , GRIN2A , IGHG1 , L1CAM , MMP14 , SDC1 , SDC4 |
ADAM10 | ADAM10 and ADAM17, ADAM10|MMP14|MMP17, alpha-secretase | M10.014|M10.017|M12.210, M12.210 | meropsmerops+pmapuniprot | 9 | 14 | APP , CD40LG , CLSTN2 , CLSTN3 , FASLG , FCER2 , IL6R , TGFA , TNF |
CASP3 | CASP3 or CASP7, CASP3|GZMB, caspase-3 | C14.003, C14.003|S01.010 | meropsuniprot | 8 | 12 | BAX , BCL2 , BCL2L1 , CD247 , GSDMD , LRBA , MCL1 , PLA2G6 |
CTSG | CTSG|F2|PLG, thrombin and CTSG | S01.133, S01.133|S01.151|S01.217|S01.233, S01.133|S01.269 | hprd+meropshprd+merops+pmapmeropsmerops+pmapuniprot | 8 | 16 | CDH5 , F2R , F2RL1 , F2RL3 , GP1BA , IGHG1 , SELPLG , VDAC1 |
ELANE | — | S01.131 | hprd+meropshprd+merops+pmapmeropsuniprot | 8 | 19 | ATP1B3 , CDH5 , F2R , F2RL1 , GSDMB , IGHG1 , MICOS13 , SCNN1G |
CTSL | papain | C01.032 | meropsuniprot | 7 | 7 | AADAC , ABCA3 , CLIC1 , GOLM2 , GSDMD , LRBA , PCDH15 |
KLK5 | KLK14|KLK5|KLK6 | S01.017, S01.017|S01.029|S01.236 | meropsmerops+pmap | 6 | 13 | DSG1 , F2R , F2RL1 , F2RL3 , MEP1A , MEP1B |
PSEN1 | PS1, gamma-secretase; site 1 | A22.001 | meropsuniprot | 6 | 7 | APP , CD44 , CREB3 , CREB3L3 , CREB3L4 , FLT1 |
CASP1 | caspase-1 | C14.001 | meropsuniprot | 5 | 5 | BCL2L1 , GSDMD , MGAM2 , ST14 , VLDLR |
CTSB | — | C01.060 | merops | 5 | 12 | APP , CLCA4 , MCOLN1 , PCNX3 , TMEM259 |
KLK6 | KLK14|KLK5|KLK6, KLK14|KLK6 | S01.017|S01.029|S01.236, S01.029|S01.151|S01.236, S01.029|S01.236, S01.236 | meropsmerops+pmap | 5 | 16 | APP , DSG1 , F2R , F2RL1 , F2RL3 |
MMP9 | ECE1|IDE|MMP9, MMP2|MMP7|MMP9 | M10.003|M10.004|M10.008, M10.004, M10.004|M13.002|M16.002 | meropsmerops+uniprotuniprot | 5 | 10 | APP , DAG1 , NINJ1 , SDC1 , SDC4 |
ADAM8 | ADAM8|ADAM9|MMP17 | M10.017|M12.208|M12.209, M12.208 | meropsmerops+pmapuniprot | 4 | 8 | APP , CHL1 , FCER2 , TNF |
CAPN1 | CAPN1|CAPN2 | C02.001, C02.001|C02.002 | hprd+meropshprd+merops+pmapmerops | 4 | 13 | BAX , BCL2L1 , F2R , F2RL1 |
GZMA | granzyme A | S01.135 | meropsuniprot | 4 | 5 | CALHM1 , F2R , GSDMB , TMPO |
KLK14 | KLK14|KLK5|KLK6, KLK14|KLK6 | S01.017|S01.029|S01.236, S01.029, S01.029|S01.151|S01.236, S01.029|S01.236 | meropsmerops+pmap | 4 | 9 | DSG1 , F2R , F2RL1 , F2RL3 |
MMP3 | — | M10.005 | meropsmerops+pmap | 4 | 4 | HBEGF , IGHG1 , IGHG3 , IGHG4 |
PRSS1 | thrombin or trypsin, trypsin, trypsin; to produce soluble form | S01.127 | merops+pmapuniprot | 4 | 4 | F2RL1 , F2RL3 , MPEG1 , TFRC |
ADAM19 | — | M12.214 | merops | 3 | 4 | ADAM19 , KITLG , TNF |
BACE1 | beta-secretase | A01.004 | meropsmerops+paperuniprot | 3 | 6 | APP , BACE1 , SELPLG |
CASP6 | CASP2|CASP6, caspase-6; when associated with variant 670-N-L-671 | C14.005, C14.005|C14.006 | hprd+meropsmeropsuniprot | 3 | 3 | APP , LRBA , TEX2 |
CTSS | — | C01.034 | merops | 3 | 15 | CD74 , IGF2R , SCAI |
LGMN | — | C13.004 | meropsuniprot | 3 | 9 | CD74 , IGHG1 , MPEG1 |
MMP17 | ADAM10|MMP14|MMP17, ADAM8|ADAM9|MMP17, MMP14|MMP17 | M10.014|M10.017, M10.014|M10.017|M12.210, M10.017, M10.017|M12.208|M12.209 | merops | 3 | 5 | APP , HBEGF , TNF |
PRSS3 | — | S01.174 | merops | 3 | 3 | APP , F2R , F2RL3 |
PRTN3 | — | S01.134 | hprd+meropshprd+merops+pmapmerops | 3 | 13 | F2R , F2RL1 , PROCR |
ST14 | ST14/MT-SP1 | S01.302 | hprd+meropsmeropsuniprot | 3 | 3 | CDCP1 , F2RL1 , ST14 |
ADAM33 | — | M12.244 | merops | 2 | 2 | APP , TNFSF11 |
ADAM9 | ADAM8|ADAM9|MMP17 | M10.017|M12.208|M12.209, M12.209 | meropsmerops+pmap | 2 | 2 | APP , TNF |
BACE2 | — | A01.041 | hprd+merops+pmapmerops | 2 | 11 | APP , BACE2 |
CAPN2 | CAPN1|CAPN2 | C02.001|C02.002, C02.002 | hprd+meropsmerops | 2 | 9 | BAX , F2RL1 |
CASP7 | CASP3 or CASP7 | C14.004 | meropsuniprot | 2 | 2 | GSDMD , PTGFRN |
CTSD | — | A01.009 | hprd+meropsmerops | 2 | 11 | APP , DCD |
HTRA2 | — | S01.278 | merops | 2 | 5 | APP , HTRA2 |
IDE | ECE1|IDE, ECE1|IDE|MME, ECE1|IDE|MMP9, IDE|MME | M10.004|M13.002|M16.002, M13.001|M13.002|M16.002, M13.001|M16.002, M13.002|M16.002, M16.002 | merops | 2 | 21 | APP , TGFA |
PARL | — | S54.009 | meropsuniprot | 2 | 2 | PGAM5 , PINK1 |
PLAU | PLAU in invasive prostate cancer, urokinase | S01.231 | meropsuniprot | 2 | 3 | ITGA6 , ITGA7 |
RHBDD1 | RHBDL4/RHBDD1 | — | uniprot | 2 | 2 | BIK , STEAP3 |
TPSB2 | — | S01.143 | hprd+meropsmerops+pmap | 2 | 5 | F2R , F2RL1 |
ACE | — | M02.001 | meropsuniprot | 1 | 3 | APP |
ADGRL1 | — | P02.010 | merops | 1 | 1 | ADGRL1 |
ADGRL3 | — | P02.011 | merops | 1 | 1 | ADGRL3 |
APEH | — | S09.004 | merops | 1 | 3 | APP |
ASPRV1 | — | A28.004 | meropsmerops+uniprot | 1 | 3 | ASPRV1 |
ASTL | — | — | uniprot | 1 | 1 | ZP2 |
BLMH | — | C01.084 | merops | 1 | 3 | APP |
BMP1 | — | — | uniprot | 1 | 1 | GLDN |
CAPS3 | CAPS3, CAPS6 and CAPS9 | — | uniprot | 1 | 1 | GSDMB |
CAPS6 | CAPS3, CAPS6 and CAPS9 | — | uniprot | 1 | 1 | GSDMB |
CAPS9 | CAPS3, CAPS6 and CAPS9 | — | uniprot | 1 | 1 | GSDMB |
CASP2 | CASP2|CASP6 | C14.005|C14.006 | merops | 1 | 1 | LRBA |
CASP4 | caspases CASP1, CASP4, CASP5 and CASP8 | — | uniprot | 1 | 1 | GSDMD |
CASP5 | caspases CASP1, CASP4, CASP5 and CASP8 | — | uniprot | 1 | 1 | GSDMD |
CASP8 | caspases CASP1, CASP4, CASP5 and CASP8 | — | uniprot | 1 | 1 | GSDMD |
CELA1 | — | S01.153 | merops | 1 | 1 | SCNN1G |
CLCA2 | — | M87.003 | merops | 1 | 1 | CLCA2 |
CLCA4 | — | M87.002 | merops | 1 | 1 | CLCA4 |
CMA1 | — | S01.140 | merops | 1 | 1 | KITLG |
CORIN | — | S01.019 | merops | 1 | 2 | CORIN |
CPM | — | M14.006 | merops | 1 | 1 | EGF |
CTRB1 | CTRB1;CTRB2 | S01.152 | merops | 1 | 4 | C5AR1 |
CTRB2 | CTRB1;CTRB2 | S01.152 | merops | 1 | 4 | C5AR1 |
CTSA | — | S10.002 | merops | 1 | 1 | LAMP2 |
CTSE | — | A01.010 | merops | 1 | 2 | APP |
CTSK | — | C01.036 | merops | 1 | 1 | ATP1B3 |
DAG1 | — | S72.001 | merops | 1 | 1 | DAG1 |
DDI2 | — | — | uniprot | 1 | 1 | NFE2L1 |
ECE1 | ECE1|IDE, ECE1|IDE|MME, ECE1|IDE|MMP9 | M10.004|M13.002|M16.002, M13.001|M13.002|M16.002, M13.002|M16.002 | merops | 1 | 4 | APP |
ERAP2 | — | M01.024 | merops | 1 | 4 | PMEL |
GZMM | — | S01.139 | merops | 1 | 1 | DCD |
HM13 | HM13/SPP | — | uniprot | 1 | 1 | XBP1 |
HPN | — | S01.224 | merops+pmap | 1 | 1 | HPN |
HTRA1 | — | S01.277 | merops | 1 | 3 | APP |
KLK1 | — | S01.160 | merops | 1 | 2 | DSG1 |
KLK13 | — | S01.306 | merops | 1 | 1 | CDH16 |
MME | ECE1|IDE|MME, IDE|MME | M13.001|M13.002|M16.002, M13.001|M16.002 | merops | 1 | 2 | APP |
MMEL1 | — | M13.008 | merops | 1 | 2 | APP |
MMP1 | — | M10.001 | merops | 1 | 1 | F2R |
MMP12 | — | M10.009 | merops | 1 | 1 | IGHG1 |
MMP16 | — | M10.016 | merops | 1 | 4 | APP |
MMP8 | — | M10.002 | merops | 1 | 1 | EFNB1 |
MUC1 | — | S71.001 | merops | 1 | 1 | MUC1 |
PGA3 | PGA3;PGA4 | A01.001 | merops | 1 | 1 | IGHG1 |
PGA4 | PGA3;PGA4, PGA4;PGA5 | A01.001, A01.070 | merops | 1 | 2 | IGHG1 |
PGA5 | PGA4;PGA5 | A01.070 | merops | 1 | 1 | IGHG1 |
PIGK | — | C13.005 | merops | 1 | 1 | ALPP |
PITRM1 | — | M16.009 | merops | 1 | 9 | APP |
PKD1L2 | — | P02.038 | merops | 1 | 1 | PKD1 |
PLAT | — | S01.232 | merops | 1 | 1 | GRIN1 |
PRCP | — | S28.001 | merops | 1 | 1 | GPR37L1 |
PRSS8 | — | — | uniprot | 1 | 1 | SCNN1G |
SPPL2A | SPPL2A or SPPL2B | A22.007 | meropsuniprot | 1 | 2 | TNF |
SPPL2B | SPPL2A or SPPL2B | A22.004 | meropsuniprot | 1 | 2 | TNF |
SPPL3 | — | — | uniprot | 1 | 1 | CLN5 |