Browse proteases
369 proteases with experimental cleavage evidence across the atlas.
| Protease | Gene / alias | MEROPS | Sources | Substrates | Sites | Example substrates |
|---|---|---|---|---|---|---|
— | — | — | merops+uniprotuniprot | 1429 | 1429 | ACE , ACE2 , ACP2 , ACP4 , ACVR1 , ACVR1B , ACVR1C , ACVR2A , ACVR2B , ACVRL1 , +1419 |
XS26.001 | — | XS26.001 | meropsmerops+uniprot | 174 | 174 | ADAM17 , ADAM32 , ADGRG1 , ADGRG3 , ALPP , APP , BAMBI , BCAM , BOC , BTN3A3 , +164 |
— | — | — | uniprot | 91 | 91 | ANO8 , ATAD3A , ATF6B , ATP5MF , ATP5MK , BAK1 , BCS1L , C3orf33 , CDAN1 , CERS1 , +81 |
M35.004 | — | M35.004 | merops | 76 | 129 | ABCA10 , ABCA6 , ABHD2 , ADAM29 , ADGRF1 , ADGRV1 , ALG9 , ASIC3 , ATP8A2 , ATRN , +66 |
CLE_M24 | — | CLE_M24 | merops | 62 | 62 | ABCD3 , ATAD3A , ATF6B , ATP5MF , ATP5MK , CDAN1 , CISD2 , CLIC1 , CLIC4 , CLPTM1 , +52 |
— | — | — | uniprot | 58 | 58 | ABCB10 , ABCB7 , ABCB8 , AFG3L2 , APOOL , ATP5MC1 , ATP5MC2 , ATP5MC3 , CCDC51 , CCDC90B , +48 |
— | — | — | hprd+uniprotpaper+uniprotuniprot | 57 | 62 | ACE , ADAM9 , ADGRB1 , ADGRF5 , ADGRG6 , ASAH2 , CD40LG , CLSTN1 , CORIN , DBH , +47 |
MBTPS1 | autolysis | P02.001, S08.063 | hprd+uniprotmeropsmerops+uniprotuniprot | 43 | 50 | ADGRB2 , ADGRD1 , ADGRE2 , ADGRE3 , ADGRE4P , ADGRE5 , ADGRF1 , ADGRF3 , ADGRF5 , ADGRG1 , +33 |
PLG | — | S01.151, S01.233 | hprd+meropshprd+merops+pmapmeropsmerops+pmap | 42 | 91 | ABCC12 , APMAP , APP , ATP1B3 , BSG , CANX , CD81 , CLIC1 , CLIC4 , CNNM4 , +32 |
MEP1B | — | M12.004 | merops | 36 | 52 | ADAM10 , ADAM15 , ADAM9 , ANKAR , APLP2 , APP , ASPH , CANX , CD99 , CLIC1 , +26 |
FURIN | furin | S08.071 | hprd+merops+pmaphprd+merops+pmap+uniprotmeropsmerops+uniprotuniprot | 36 | 41 | ADAM10 , ADAM12 , ADAM15 , ADAM19 , ADAM8 , ADGRB2 , ADGRF5 , ATP6AP1 , BACE1 , CNMD , +26 |
S01.280 | — | S01.280 | merops | 35 | 57 | ABCA3 , ADAM30 , AJAP1 , ALG6 , ATP2C1 , B3GALT1 , BLTP1 , CCDC47 , CDS2 , CHST4 , +25 |
PCSK5 | — | S08.076 | merops | 28 | 29 | ADAM10 , ADAM12 , ADAM17 , ADAM19 , ADAM8 , BACE1 , EDA , FURIN , HBEGF , INSR , +18 |
PCSK4 | — | S08.074 | merops | 27 | 28 | ADAM10 , ADAM12 , ADAM17 , ADAM19 , ADAM8 , BACE1 , EDA , FURIN , HBEGF , INSR , +17 |
PCSK6 | — | S08.075 | merops | 27 | 28 | ADAM10 , ADAM12 , ADAM17 , ADAM19 , ADAM8 , BACE1 , EDA , FURIN , HBEGF , INSR , +17 |
PCSK7 | — | S08.077 | merops | 27 | 28 | ADAM10 , ADAM12 , ADAM17 , ADAM19 , ADAM8 , BACE1 , EDA , FURIN , HBEGF , INSR , +17 |
MMP2 | — | M10.003 | hprd+merops+pmapmerops | 26 | 32 | ADGRG1 , APMAP , APP , CADM1 , CLIC1 , CLIC4 , CSPG4 , EPHB1 , FGFR1 , GRM4 , +16 |
PCSK2 | — | S08.073 | merops | 24 | 25 | ADAM10 , ADAM17 , ADAM19 , ADAM8 , BACE1 , EDA , FURIN , HBEGF , INSR , ITGA3 , +14 |
MEP1A | — | M12.002 | merops | 21 | 30 | ADAM9 , APP , ASPH , CLIC1 , CLSTN1 , DSC3 , DSG3 , DSG4 , F11R , FAT2 , +11 |
— | — | — | uniprot | 19 | 20 | AFG3L2 , ALPP , BST2 , BTC , CLN3 , EREG , NAGPA , PTGIR , RAET1G , SLC25A1 , +9 |
GZMB | — | S01.010 | hprd+meropsmerops | 18 | 23 | CACNA1C , CHRNA7 , CLIC1 , CLIC2 , CNGA1 , DLL1 , DSG2 , F2R , GRIA3 , GRIA4 , +8 |
ADAM17 | — | M12.217 | hprd+merops+pmapmeropsmerops+pmapuniprot | 16 | 27 | ACE , APP , AREG , BTC , CLSTN2 , CLSTN3 , ERBB4 , EREG , FCGR3A , GP1BA , +6 |
CLE_C14 | — | CLE_C14 | merops | 13 | 13 | CELSR2 , CYB5B , LRCH4 , MAN1A1 , MIA3 , NOTCH4 , OSBPL8 , SEMA4C , SLC25A46 , SLC4A3 , +3 |
KLK4 | — | S01.251 | merops | 13 | 13 | BACE1 , CDH1 , CDH2 , CDH3 , CDH4 , CDH5 , DSG1 , DSG3 , EPCAM , F2RL1 , +3 |
MMP14 | — | M10.014 | hprd+meropshprd+merops+pmapmeropsmerops+papermerops+pmapuniprot | 12 | 32 | APP , BCAM , BSG , CD44 , CDH1 , HBEGF , ITGAV , MMP14 , PTK7 , SDC1 , +2 |
MMP7 | — | M10.008 | meropsmerops+papermerops+pmap | 12 | 18 | ADAM28 , CDH1 , FAS , FASLG , IGHG1 , IGHG3 , IGHG4 , ITGB4 , MAG , OCLN , +2 |
S01.269 | — | S01.269 | merops | 10 | 17 | CANX , CD81 , CLIC1 , CSPG4 , IGHG1 , ITGAE , NNT , SELE , SLC25A29 , VDAC1 |
CLE_UNK | — | CLE_UNK | merops | 8 | 9 | ATP1A1 , COX4I1 , CYC1 , ITGA6 , LETM1 , NDUFB11 , ST14 , UQCRFS1 |
M12.033 | — | M12.033 | merops | 8 | 8 | CANX , CLIC4 , EBP , FKBP8 , MT-CO2 , NRXN3 , TMEM151A , VDAC3 |
ADAM10 | — | M12.210 | meropsmerops+pmapuniprot | 8 | 13 | APP , CD40LG , CLSTN2 , CLSTN3 , FASLG , FCER2 , TGFA , TNF |
ELANE | — | S01.131 | hprd+meropshprd+merops+pmapmeropsuniprot | 8 | 19 | ATP1B3 , CDH5 , F2R , F2RL1 , GSDMB , IGHG1 , MICOS13 , SCNN1G |
CTSG | — | S01.133 | hprd+meropshprd+merops+pmapmeropsmerops+pmapuniprot | 8 | 17 | CDH5 , F2R , F2RL1 , F2RL3 , GP1BA , IGHG1 , SELPLG , VDAC1 |
F2 | — | S01.217 | hprd+meropsmeropsmerops+pmap | 7 | 9 | CLIC1 , F2R , F2RL1 , F2RL2 , F2RL3 , GP5 , SDC4 |
CASP3 | — | C14.003 | merops | 7 | 11 | BAX , BCL2 , BCL2L1 , CD247 , LRBA , MCL1 , PLA2G6 |
furin-like protease | — | — | uniprot | 7 | 8 | ADAM9 , ATP6AP2 , GLDN , LFNG , MMP23B , NOTCH1 , NOTCH3 |
CTSL | — | C01.032 | meropsuniprot | 6 | 6 | AADAC , ABCA3 , CLIC1 , GOLM2 , LRBA , PCDH15 |
METAP1D | — | M24.028 | meropsmerops+uniprot | 6 | 6 | DNAJC19 , MAOB , SFXN1 , SLC25A4 , SLC25A5 , VDAC1 |
KLK5 | — | S01.017 | meropsmerops+pmap | 6 | 13 | DSG1 , F2R , F2RL1 , F2RL3 , MEP1A , MEP1B |
KLK6 | — | S01.236 | meropsmerops+pmap | 5 | 16 | APP , DSG1 , F2R , F2RL1 , F2RL3 |
CTSB | — | C01.060 | merops | 5 | 12 | APP , CLCA4 , MCOLN1 , PCNX3 , TMEM259 |
MMP9 | — | M10.004 | meropsmerops+uniprotuniprot | 5 | 10 | APP , DAG1 , NINJ1 , SDC1 , SDC4 |
M12.001 | — | M12.001 | merops | 5 | 5 | ARMH4 , CANX , NLGN3 , PCDHB5 , SELL |
CASP1 | — | C14.001 | merops | 5 | 5 | BCL2L1 , GSDMD , MGAM2 , ST14 , VLDLR |
thrombin | — | — | uniprot | 4 | 5 | ADGRA2 , C9 , F2RL2 , SLC10A4 |
ADAM8 | — | M12.208 | meropsmerops+pmapuniprot | 4 | 8 | APP , CHL1 , FCER2 , TNF |
MMP3 | — | M10.005 | meropsmerops+pmap | 4 | 4 | HBEGF , IGHG1 , IGHG3 , IGHG4 |
C01.073 | — | C01.073 | merops | 4 | 10 | CD209 , CLEC4M , FCER2 , OCLN |
CAPN1 | — | C02.001 | hprd+meropshprd+merops+pmapmerops | 4 | 13 | BAX , BCL2L1 , F2R , F2RL1 |
KLK14 | — | S01.029 | meropsmerops+pmap | 4 | 9 | DSG1 , F2R , F2RL1 , F2RL3 |
— | — | — | uniprot | 3 | 3 | F2RL1 , F2RL2 , F2RL3 |
A02.001 | — | A02.001 | merops | 3 | 4 | APP , CLIC1 , CNNM4 |
PS1 | — | — | uniprot | 3 | 4 | CREB3 , CREB3L3 , CREB3L4 |
— | — | — | uniprot | 3 | 3 | SDC2 , SDC3 , TREM2 |
MMP17 | — | M10.017 | merops | 3 | 5 | APP , HBEGF , TNF |
ADAM19 | — | M12.214 | merops | 3 | 4 | ADAM19 , KITLG , TNF |
LGMN | — | C13.004 | meropsuniprot | 3 | 9 | CD74 , IGHG1 , MPEG1 |
C01.033 | — | C01.033 | merops | 3 | 3 | IGHG2 , IGHG3 , IGHG4 |
CTSS | — | C01.034 | merops | 3 | 15 | CD74 , IGF2R , SCAI |
PRSS3 | — | S01.174 | merops | 3 | 3 | APP , F2R , F2RL3 |
BACE1 | — | A01.004 | meropsmerops+paper | 3 | 6 | APP , BACE1 , SELPLG |
CASP6 | — | C14.005 | hprd+meropsmerops | 3 | 3 | APP , LRBA , TEX2 |
PSEN1 | — | A22.001 | meropsuniprot | 3 | 3 | APP , CD44 , FLT1 |
GZMA | — | S01.135 | merops | 3 | 3 | CALHM1 , F2R , TMPO |
PRTN3 | — | S01.134 | hprd+meropshprd+merops+pmapmerops | 3 | 13 | F2R , F2RL1 , PROCR |
ST14 | — | S01.302 | hprd+meropsmerops | 3 | 3 | CDCP1 , F2RL1 , ST14 |
PARL | — | S54.009 | meropsmerops+uniprotuniprot | 3 | 3 | PARL , PGAM5 , PINK1 |
ADAM33 | — | M12.244 | merops | 2 | 2 | APP , TNFSF11 |
proprotein convertases | — | — | uniprot | 2 | 2 | PLXNB1 , PLXNB2 |
HTRA2 | — | S01.278 | merops | 2 | 5 | APP , HTRA2 |
IDE | — | M16.002 | merops | 2 | 21 | APP , TGFA |
ADAM9 | — | M12.209 | meropsmerops+pmap | 2 | 2 | APP , TNF |
C25.002 | — | C25.002 | meropsmerops+pmap | 2 | 5 | C5AR1 , TNF |
C66.001 | — | C66.001 | merops | 2 | 2 | IGHG1 , IGHG3 |
M64.001 | — | M64.001 | merops | 2 | 2 | IGHA1 , IGHA2 |
CTSD | — | A01.009 | hprd+meropsmerops | 2 | 11 | APP , DCD |
BACE2 | — | A01.041 | hprd+merops+pmapmerops | 2 | 11 | APP , BACE2 |
M12.167 | — | M12.167 | merops | 2 | 2 | GP1BA , SELPLG |
M10.039 | — | M10.039 | merops | 2 | 3 | FURIN , MMP14 |
caspase-3 | — | — | uniprot | 2 | 3 | BCL2 , MCL1 |
S.pyogenes SpeB | — | — | uniprot | 2 | 3 | CDH1 , GSDMA |
a metalloproteinase | — | — | uniprot | 2 | 2 | CDH1 , EPHB2 |
— | — | — | uniprot | 2 | 2 | B4GALT1 , CX3CL1 |
KLK1 | — | S01.160 | merops | 2 | 3 | DSG1 , F2R |
TPSB2 | — | S01.143 | hprd+meropsmerops+pmap | 2 | 5 | F2R , F2RL1 |
S01.001 | — | S01.001 | merops | 2 | 3 | CADM1 , F2R |
CLE_S26 | — | CLE_S26 | merops | 2 | 2 | CANX , SSR2 |
XT01.001 | — | XT01.001 | merops | 2 | 20 | DCT , PMEL |
trypsin | — | — | uniprot | 2 | 2 | F2RL1 , MPEG1 |
CAPN2 | — | C02.002 | hprd+meropsmerops | 2 | 9 | BAX , F2RL1 |
C11.001 | — | C11.001 | merops | 2 | 4 | BACE1 , IL20RA |
— | — | — | uniprot | 2 | 2 | ERVPABLB-1 , ERVS71-1 |
RHBDL4/RHBDD1 | — | — | uniprot | 2 | 2 | BIK , STEAP3 |
— | — | — | uniprot | 1 | 1 | GGT3P |
— | — | — | uniprot | 1 | 1 | SLN |
— | — | — | uniprot | 1 | 1 | NRG2 |
— | — | — | uniprot | 1 | 1 | ADGRB1 |
furin and PCSK7 | — | — | uniprot | 1 | 1 | ADAM10 |
— | — | — | uniprot | 1 | 1 | EREG |
— | — | — | uniprot | 1 | 1 | TMPRSS2 |
— | — | — | uniprot | 1 | 1 | TMPRSS11D |
M41.003 | — | M41.003 | merops | 1 | 2 | OPA1 |
— | — | — | uniprot | 1 | 1 | OPA1 |
— | — | — | uniprot | 1 | 2 | OPA1 |
PRCP | — | S28.001 | merops | 1 | 1 | GPR37L1 |
KLK13 | — | S01.306 | merops | 1 | 1 | CDH16 |
SPPL3 | — | — | uniprot | 1 | 1 | CLN5 |
— | — | — | uniprot | 1 | 1 | CLN5 |
— | — | — | uniprot | 1 | 1 | ATP6AP2 |
— | — | — | uniprot | 1 | 1 | ATP6AP2 |
— | — | — | uniprot | 1 | 1 | CNMD |
ADGRL1 | — | P02.010 | merops | 1 | 1 | ADGRL1 |
— | — | — | uniprot | 1 | 1 | CLSTN1 |
— | — | — | uniprot | 1 | 2 | EGF |
CPM | — | M14.006 | merops | 1 | 1 | EGF |
— | — | — | uniprot | 1 | 1 | TGFA |
SPPL2B | — | A22.004 | merops | 1 | 2 | TNF |
SPPL2A | — | A22.007 | merops | 1 | 2 | TNF |
SPPL2A or SPPL2B | — | — | uniprot | 1 | 2 | TNF |
— | — | — | uniprot | 1 | 1 | TNF |
— | — | — | uniprot | 1 | 1 | TNF |
— | — | — | uniprot | 1 | 1 | TNF |
C25.001 | — | C25.001 | merops+pmap | 1 | 2 | TNF |
C25.003 | — | C25.003 | merops+pmap | 1 | 1 | TNF |
— | — | — | uniprot | 1 | 1 | PIGR |
C01.001 | — | C01.001 | merops | 1 | 2 | IGHG1 |
MMP12 | — | M10.009 | merops | 1 | 1 | IGHG1 |
PGA4;PGA5 | — | A01.070 | merops | 1 | 1 | IGHG1 |
PGA3;PGA4 | — | A01.001 | merops | 1 | 1 | IGHG1 |
M26.001 | — | M26.001 | merops | 1 | 1 | IGHA1 |
S06.007 | — | S06.007 | merops | 1 | 1 | IGHA1 |
U9G.049 | — | U9G.049 | merops | 1 | 1 | IGHA2 |
M9G.002 | — | M9G.002 | merops | 1 | 1 | GYPA |
— | — | — | uniprot | 1 | 1 | C9 |
trypsin; to produce soluble form | — | — | uniprot | 1 | 1 | TFRC |
— | — | — | uniprot | 1 | 1 | TFRC |
— | — | — | uniprot | 1 | 2 | CD74 |
A32.002 | — | A32.002 | merops | 1 | 1 | RPN1 |
caspases | — | — | uniprot | 1 | 2 | APP |
— | — | — | uniprot | 1 | 1 | APP |
C47.003 | — | C47.003 | merops | 1 | 2 | APP |
MMP16 | — | M10.016 | merops | 1 | 4 | APP |
S9G.058 | — | S9G.058 | merops | 1 | 2 | APP |
— | — | — | uniprot | 1 | 1 | APP |
beta-secretase | — | — | uniprot | 1 | 1 | APP |
HTRA1 | — | S01.277 | merops | 1 | 3 | APP |
U9G.071 | — | U9G.071 | merops | 1 | 3 | APP |
caspase-6; when associated with variant 670-N-L-671 | — | — | uniprot | 1 | 1 | APP |
MME | — | M13.001 | merops | 1 | 2 | APP |
ECE1 | — | M13.002 | merops | 1 | 4 | APP |
S01.243 | — | S01.243 | merops | 1 | 4 | APP |
ACE | — | M02.001 | meropsuniprot | 1 | 3 | APP |
U9G.055 | — | U9G.055 | merops | 1 | 1 | APP |
S01.422 | — | S01.422 | merops | 1 | 5 | APP |
APEH | — | S09.004 | merops | 1 | 3 | APP |
BLMH | — | C01.084 | merops | 1 | 3 | APP |
M9G.026 | — | M9G.026 | merops | 1 | 3 | APP |
C04.001 | — | C04.001 | merops | 1 | 1 | APP |
PITRM1 | — | M16.009 | merops | 1 | 9 | APP |
A01.035 | — | A01.035 | merops | 1 | 1 | APP |
MMEL1 | — | M13.008 | merops | 1 | 2 | APP |
— | — | — | uniprot | 1 | 1 | APP |
alpha-secretase | — | — | uniprot | 1 | 1 | APP |
CTSE | — | A01.010 | merops | 1 | 2 | APP |
theta-secretase | — | — | uniprot | 1 | 1 | APP |
— | — | — | uniprot | 1 | 1 | APP |
A22.015 | — | A22.015 | merops | 1 | 2 | APP |
— | — | — | uniprot | 1 | 1 | APP |
gamma-secretase; site 1 | — | — | uniprot | 1 | 1 | APP |
PIGK | — | C13.005 | merops | 1 | 1 | ALPP |
— | — | — | uniprot | 1 | 1 | ALPP |
HPN | — | S01.224 | merops+pmap | 1 | 1 | HPN |
— | — | — | uniprot | 1 | 1 | HPN |
— | — | — | uniprot | 1 | 1 | INSR |
— | — | — | uniprot | 1 | 1 | INSR |
— | — | — | uniprot | 1 | 1 | ITGAV |
— | — | — | uniprot | 1 | 1 | ITGAV |
— | — | — | uniprot | 1 | 1 | GP1BA |
— | — | — | uniprot | 1 | 1 | IGF1R |
— | — | — | uniprot | 1 | 1 | IGF1R |
— | — | — | uniprot | 1 | 1 | ITGA2B |
— | — | — | uniprot | 1 | 1 | ITGA2B |
— | — | — | uniprot | 1 | 1 | ITGA2B |
— | — | — | uniprot | 1 | 1 | ITGA5 |
— | — | — | uniprot | 1 | 1 | IL6R |
ADAM10 and ADAM17 | — | — | uniprot | 1 | 1 | IL6R |
— | — | — | uniprot | 1 | 1 | CSF1 |
— | — | — | uniprot | 1 | 1 | CSF1 |
— | — | — | uniprot | 1 | 1 | LCT |
— | — | — | uniprot | 1 | 1 | FURIN |
— | — | — | uniprot | 1 | 1 | GHR |
— | — | — | uniprot | 1 | 1 | CDH1 |
CTSA | — | S10.002 | merops | 1 | 1 | LAMP2 |
— | — | — | uniprot | 1 | 1 | SI |
— | — | — | uniprot | 1 | 1 | INSRR |
— | — | — | uniprot | 1 | 1 | INSRR |
— | — | — | uniprot | 1 | 1 | AREG |
— | — | — | uniprot | 1 | 1 | CD1E |
MUC1 | — | S71.001 | merops | 1 | 1 | MUC1 |
— | — | — | uniprot | 1 | 1 | MUC1 |
— | — | — | uniprot | 1 | 1 | ABO |
HM13/SPP | — | — | uniprot | 1 | 1 | XBP1 |
— | — | — | uniprot | 1 | 1 | XBP1 |
— | — | — | uniprot | 1 | 2 | TNFRSF1A |
— | — | — | uniprot | 1 | 1 | GGT1 |
— | — | — | uniprot | 1 | 1 | TNFRSF1B |
CMA1 | — | S01.140 | merops | 1 | 1 | KITLG |
— | — | — | uniprot | 1 | 1 | KITLG |
CTRB1;CTRB2 | — | S01.152 | merops | 1 | 4 | C5AR1 |
— | — | — | uniprot | 1 | 1 | ZP3 |
PLAU | — | S01.231 | merops | 1 | 1 | ITGA6 |
PLAU in invasive prostate cancer | — | — | uniprot | 1 | 1 | ITGA6 |
— | — | — | uniprot | 1 | 1 | ITGA6 |
— | — | — | uniprot | 1 | 1 | ITGA6 |
— | — | — | uniprot | 1 | 1 | ITGA6 |
Staphylococcus aureus/SspP | — | — | uniprot | 1 | 1 | CXCR2 |
MMP1 | — | M10.001 | merops | 1 | 1 | F2R |
F10 | — | S01.216 | merops | 1 | 1 | F2R |
PROC | — | S01.218 | merops | 1 | 1 | F2R |
thrombin and CTSG | — | — | uniprot | 1 | 1 | F2R |
— | — | — | uniprot | 1 | 1 | ITGA3 |
— | — | — | uniprot | 1 | 1 | ITGA3 |
— | — | — | uniprot | 1 | 1 | DPP4 |
— | — | — | uniprot | 1 | 1 | EPHB2 |
M08.001 | — | M08.001 | merops | 1 | 1 | ABCC1 |
— | — | — | uniprot | 1 | 1 | BTC |
— | — | — | uniprot | 1 | 1 | GGT5 |
— | — | — | uniprot | 1 | 2 | SCNN1A |
— | — | — | uniprot | 1 | 1 | ITGAE |
— | — | — | uniprot | 1 | 1 | ITGAE |
XT01.003 | — | XT01.003 | merops | 1 | 2 | DCT |
ERAP2 | — | M01.024 | merops | 1 | 4 | PMEL |
— | — | — | uniprot | 1 | 1 | PMEL |
furin-like proprotein convertase | — | — | uniprot | 1 | 1 | PMEL |
— | — | — | uniprot | 1 | 1 | PMEL |
ADAM metalloproteinases | — | — | uniprot | 1 | 1 | PMEL |
— | — | — | uniprot | 1 | 2 | TMPO |
— | — | — | uniprot | 1 | 1 | TMPO |
— | — | — | uniprot | 1 | 1 | NOTCH1 |
— | — | — | uniprot | 1 | 1 | UQCRFS1 |
— | — | — | uniprot | 1 | 1 | FASLG |
— | — | — | uniprot | 1 | 1 | ADGRE5 |
CASP2 | — | C14.006 | merops | 1 | 1 | LRBA |
PRSS8 | — | — | uniprot | 1 | 1 | SCNN1G |
CELA1 | — | S01.153 | merops | 1 | 1 | SCNN1G |
— | — | — | uniprot | 1 | 1 | ITGA8 |
— | — | — | uniprot | 1 | 1 | CACNA2D1 |
CTSK | — | C01.036 | merops | 1 | 1 | ATP1B3 |
C01.072 | — | C01.072 | merops | 1 | 1 | F2RL1 |
PRSS1 | — | S01.127 | merops+pmap | 1 | 1 | F2RL1 |
M04.005 | — | M04.005 | merops | 1 | 2 | F2RL1 |
— | — | — | uniprot | 1 | 1 | F2RL1 |
— | — | — | uniprot | 1 | 1 | F2RL1 |
— | — | — | uniprot | 1 | 1 | NRG3 |
CASP3 or CASP7 | — | — | uniprot | 1 | 1 | GSDMD |
— | — | — | uniprot | 1 | 1 | GSDMD |
enterovirus 71 (EV71) Protease 3C and coronavirus SARS-CoV-2 proteinase nsp5 | — | — | uniprot | 1 | 1 | GSDMD |
caspases CASP1, CASP4, CASP5 and CASP8 | — | — | uniprot | 1 | 1 | GSDMD |
— | — | — | uniprot | 1 | 1 | GSDMD |
papain | — | — | uniprot | 1 | 1 | GSDMD |
— | — | — | uniprot | 1 | 1 | GSDMD |
— | — | — | uniprot | 1 | 1 | ZP1 |
— | — | — | uniprot | 1 | 1 | DLK1 |
GZMM | — | S01.139 | merops | 1 | 1 | DCD |
— | — | — | uniprot | 1 | 1 | DCD |
— | — | — | uniprot | 1 | 1 | DCD |
— | — | — | uniprot | 1 | 1 | TMPRSS15 |
PKD1L2 | — | P02.038 | merops | 1 | 1 | PKD1 |
MMP8 | — | M10.002 | merops | 1 | 1 | EFNB1 |
— | — | — | uniprot | 1 | 1 | EFNB1 |
— | — | — | uniprot | 1 | 1 | DHODH |
— | — | — | uniprot | 1 | 1 | NRG1 |
— | — | — | uniprot | 1 | 1 | NOTCH2 |
— | — | — | uniprot | 1 | 1 | MST1R |
— | — | — | uniprot | 1 | 1 | MST1R |
PLAT | — | S01.232 | merops | 1 | 1 | GRIN1 |
ASTL | — | — | uniprot | 1 | 1 | ZP2 |
caspase-1 | — | — | uniprot | 1 | 1 | BCL2L1 |
— | — | — | uniprot | 1 | 1 | LRP1 |
— | — | — | uniprot | 1 | 1 | MGAT5 |
— | — | — | uniprot | 1 | 1 | GALNT2 |
— | — | — | uniprot | 1 | 1 | GALNT1 |
— | — | — | uniprot | 1 | 1 | BST2 |
— | — | — | uniprot | 1 | 1 | ZP4 |
urokinase | — | — | uniprot | 1 | 1 | ITGA7 |
— | — | — | uniprot | 1 | 1 | ITGA7 |
— | — | — | uniprot | 1 | 1 | ITGA7 |
— | — | — | uniprot | 1 | 1 | ITGA7 |
DAG1 | — | S72.001 | merops | 1 | 1 | DAG1 |
— | — | — | uniprot | 1 | 1 | DAG1 |
DDI2 | — | — | uniprot | 1 | 1 | NFE2L1 |
— | — | — | uniprot | 1 | 1 | NFE2L1 |
CLCA4 | — | M87.002 | merops | 1 | 1 | CLCA4 |
S08.025 | — | S08.025 | merops | 1 | 2 | OCLN |
— | — | — | uniprot | 1 | 1 | PRSS8 |
— | — | — | uniprot | 1 | 1 | PRSS8 |
— | — | — | uniprot | 1 | 1 | PRSS8 |
— | — | — | uniprot | 1 | 2 | MPEG1 |
— | — | — | uniprot | 1 | 1 | GNPTAB |
ASPRV1 | — | A28.004 | meropsmerops+uniprot | 1 | 3 | ASPRV1 |
— | — | — | uniprot | 1 | 1 | ADGRF1 |
— | — | — | uniprot | 1 | 1 | RAET1G |
— | — | — | uniprot | 1 | 1 | ADGRD1 |
— | — | — | uniprot | 1 | 2 | GLDN |
BMP1 | — | — | uniprot | 1 | 1 | GLDN |
— | — | — | uniprot | 1 | 1 | CACNA2D4 |
furin like-convertase | — | — | uniprot | 1 | 1 | ADGRG6 |
— | — | — | uniprot | 1 | 4 | CD163 |
— | — | — | uniprot | 1 | 1 | ADGRG3 |
lysosomal cysteine proteases | — | — | uniprot | 1 | 1 | PLD3 |
— | — | — | uniprot | 1 | 2 | VSTM4 |
— | — | — | uniprot | 1 | 1 | SPACA3 |
— | — | — | uniprot | 1 | 1 | ADGRG5 |
— | — | — | uniprot | 1 | 1 | ADGRG4 |
— | — | — | uniprot | 1 | 1 | ADGRG2 |
— | — | — | uniprot | 1 | 2 | SMIM20 |
— | — | — | uniprot | 1 | 1 | SMIM20 |
CAPS3, CAPS6 and CAPS9 | — | — | uniprot | 1 | 1 | GSDMB |
granzyme A | — | — | uniprot | 1 | 2 | GSDMB |
— | — | — | uniprot | 1 | 1 | GSDMB |
— | — | — | uniprot | 1 | 1 | NRG4 |
— | — | — | uniprot | 1 | 1 | STAB2 |
— | — | — | uniprot | 1 | 1 | ADGRV1 |
— | — | — | uniprot | 1 | 1 | PTPRN2 |
— | — | — | uniprot | 1 | 1 | NINJ1 |
S01.136 | — | S01.136 | merops | 1 | 1 | ABCC12 |
— | — | — | uniprot | 1 | 1 | SORCS2 |
— | — | — | uniprot | 1 | 1 | GSDMA |
thrombin or trypsin | — | — | uniprot | 1 | 1 | F2RL3 |
— | — | — | uniprot | 1 | 1 | HBEGF |
— | — | — | uniprot | 1 | 1 | HBEGF |
— | — | — | uniprot | 1 | 1 | HBEGF |
— | — | — | uniprot | 1 | 1 | NOTCH4 |
M16.003 | — | M16.003 | merops | 1 | 1 | SDHC |
— | — | — | uniprot | 1 | 1 | ABCA3 |
— | — | — | uniprot | 1 | 2 | ATF6B |
— | — | — | uniprot | 1 | 1 | COL25A1 |
autolysis; required for cell surface localization and secretion | — | — | uniprot | 1 | 1 | TMPRSS13 |
— | — | — | uniprot | 1 | 1 | TMPRSS13 |
— | — | — | uniprot | 1 | 1 | ACE2 |
ST14/MT-SP1 | — | — | uniprot | 1 | 1 | CDCP1 |
— | — | — | uniprot | 1 | 1 | ERVMER34-1 |
ADGRL3 | — | P02.011 | merops | 1 | 1 | ADGRL3 |
— | — | — | paper+uniprot | 1 | 1 | CLTRN |
M12.161 | — | M12.161 | merops | 1 | 2 | GP6 |
— | — | — | uniprot | 1 | 1 | NRXN3 |
— | — | — | uniprot | 1 | 2 | ITM2C |
— | — | — | uniprot | 1 | 1 | TPSG1 |
— | — | — | uniprot | 1 | 1 | TPSG1 |
— | — | — | uniprot | 1 | 1 | ATAD3A |
— | — | — | uniprot | 1 | 1 | CACNA2D2 |
CASP7 | — | C14.004 | merops | 1 | 1 | PTGFRN |
— | — | — | uniprot | 1 | 1 | PISD |
— | — | — | uniprot | 1 | 1 | LNPEP |
— | — | — | uniprot | 1 | 1 | GGT7 |
— | — | — | uniprot | 1 | 1 | TMPRSS11E |
— | — | — | uniprot | 1 | 1 | MGAT4A |
— | — | — | uniprot | 1 | 1 | NOTCH3 |
— | — | — | uniprot | 1 | 1 | COL17A1 |
— | — | — | uniprot | 1 | 1 | COL17A1 |
— | — | — | uniprot | 1 | 1 | CLCA2 |
CLCA2 | — | M87.003 | merops | 1 | 1 | CLCA2 |
— | — | — | uniprot | 1 | 1 | ERVW-1 |
— | — | — | uniprot | 1 | 1 | ITM2B |
— | — | — | uniprot | 1 | 1 | ITM2B |
CORIN | — | S01.019 | merops | 1 | 2 | CORIN |
— | — | — | uniprot | 1 | 1 | CORIN |
— | — | — | uniprot | 1 | 1 | CORIN |
— | — | — | uniprot | 1 | 1 | MMP24 |
— | — | — | uniprot | 1 | 1 | ADGRG1 |