HSA Human Sheddome Atlas
UniProt · Membrane protein

APP (Amyloid-Beta Precursor Protein)

P05067 · 770 aa ·Signal peptide ·1× TM · 1 predicted cleavages ·156 experimental cleavages

Cleavage peaks

Structure

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AlphaFold · pLDDT

Experimental cleavages

59 unique positions · 156 annotations · 19/59 (32%) covered by peaks
Sources (filter in the plot above): ascent+weeks21merops+uniprotpaperschaeffer22meropsuniprotweeks21hprd+meropshprd
P1 pos Sources Proteases References
17 ascent+weeks21merops+uniprotpaperschaeffer22 XS26.001 33536314 12665801 2900137 3597385 33796845 36313159
124 merops MEP1A|MEP1B 21693781
197 uniprot caspases 10319819
219 uniprot caspases 10319819
229 merops A02.001 1907279
286 uniprot N-APP —
295 paper — 33796845
301 merops PRSS3 19920152
338 paper — 33796845
380 merops MEP1B 21693781
386 paper — 33796845
396 merops C47.003 15255185
399 merops C47.003 15255185
429 ascent+weeks21 — 33536314
463 merops MMP16 16567416
579 meropspaper MMP14 , MMP16 12767235 16567416 33796845
580 paper — 33796845
608 paper — 33796845
609 merops HTRA2 16968707
610 merops A02.001 1907279
611 paper — 33796845
622 merops MMP16 16567416
624 weeks21 — 33536314
627 meropsweeks21 CTSD 8943232 33536314
668 hprd+merops CTSD 8943232
670 merops KLK6 , S9G.058 12878203 8142398
671 meropsuniprot BACE1 , BACE2 , S9G.058 , Soluble APP-beta , beta-secretase 10677483 12423367 8142398 11851430
672 hprd+meropsmeropsuniprot CASP6 , BACE2 , HTRA1 , U9G.071 , caspase-6; when associated with variant 670-N-L-671 10438520 12423367 15855271 18682830
673 merops CTSD 8943232
674 hprd+meropsmerops CTSD , BACE2 , ECE1|IDE|MME , U9G.071 8943232 12423367 16787929 18682830
675 merops CTSD , IDE , S01.243 8943232 16787929 10635572
676 merops BACE2 , ACE , PLG , KLK6 , S01.243 12423367 18085519 10818128 12878203 10635572
678 meropsuniprot U9G.055 , ACE 14741696 11604391 16154999
679 merops S01.422 10635572
681 merops CTSB 9119007
683 merops IDE , HTRA1 18470479 15855271
684 merops BACE2 , IDE , APEH 12423367 16787929 19627603
685 merops BACE2 , CTSB , BLMH , MMP16 , ADAM8|ADAM9|MMP17 , ADAM33 , IDE , M9G.026 , APEH 12423367 9119007 16472072 16567416 12135759 14676211 16787929 12128061 19627603
686 merops ADAM10 , BACE2 , C04.001 , IDE , PITRM1 , HTRA1 12423367 21187975 16787929 16849325 15855271
687 meropspaperschaeffer22uniprot A01.035 , BACE2 , CTSB , MMP2 , ECE1|IDE|MMP9 , ADAM10|MMP14|MMP17 , ADAM17 , MMEL1 , PITRM1 , PLG , KLK6 , Soluble APP-alpha , alpha-secretase 10191273 12423367 9119007 7811262 16787929 12135759 12135369 18571334 16849325 10818128 12878203 33796845 36313159 11851430
688 meropspaperschaeffer22 ECE1|IDE , MMEL1 , M9G.026 16787929 18571334 12128061 33796845 36313159
689 merops BLMH , IDE|MME , S01.422 16472072 16787929 10635572
690 hprd+meropsmeropsuniprot CTSD , CTSE , BACE2 , BLMH , ECE1|IDE , PITRM1 , M9G.026 , APEH , theta-secretase 10605825 9119007 12065613 16472072 16787929 16849325 12128061 19627603 16816112
691 uniprothprdmerops C80 , CTSD , CTSE , BACE2 , MMP9 , IDE , PITRM1 8943232 10605825 10931940 9119007 16787929 18470479 16849325
693 merops CTSD , CTSB 8943232 9119007
694 merops CTSD , MMP9 8943232 16787929
695 merops S01.422 10635572
698 merops U9G.071 18682830
699 merops IDE , PLG , S01.243 16787929 10818128 10635572
700 merops PITRM1 16849325
701 merops MMP9 , PITRM1 16787929 16849325
703 merops S01.422 10635572
704 merops CTSB , MMP9 , PITRM1 16982417 16787929 16849325
705 hprd+meropsmerops CTSD , MMP2 , MMP9 , PITRM1 , S01.243 10605825 7811262 16787929 19196155 10635572
706 merops MMP2 7811262
707 merops S01.422 10635572
708 meropspaper CTSB 16982417 33796845
709 meropspaper A22.015 , CTSB , PITRM1 20927381 9119007 16849325 33796845
711 meropspaperuniprot PSEN1 , A22.015 , CTSB , ACE , P3(40) , gamma-secretase; site 1 9450754 20927381 16982417 17687040 33796845 11851430

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Sequence

770 aa
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