UniProt · Membrane protein

ADAM17 (Disintegrin and Metalloproteinase Domain-Containing Protein 17)

P78536 · 824 aa ·Signal peptide ·Propeptide ·1× TM · 5 predicted cleavages ·10 experimental cleavages

Cleavage peaks

Domain source Stringency Domain labels Peak lines Peak labels

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Colour: Topology pLDDT

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AlphaFold · pLDDT

4 unique positions · 10 annotations · 3/4 (75%) covered by peaks

Sources (filter in the plot above): meropsuniprotschaeffer22weeks21

P1 pos	Sources	Proteases	References
`17`	meropsuniprot	XS26.001 , Signal peptidase	16518876
`214`	meropsuniprot	PCSK2 , PCSK4 , PCSK6 , PCSK5 , PCSK7	18505722 9034191
`215`	schaeffer22	—	36313163
`465`	weeks21	—	33526672

824 aa

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