HSA Human Sheddome Atlas
UniProt · Membrane protein

ADAM10 (Disintegrin and Metalloproteinase Domain-Containing Protein 10)

O14672 · 748 aa ·Signal peptide ·Propeptide ·1× TM · 7 predicted cleavages ·30 experimental cleavages

Cleavage peaks

Structure

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AlphaFold · pLDDT

Experimental cleavages

14 unique positions · 30 annotations · 12/14 (86%) covered by peaks
Sources (filter in the plot above): topfindascentschaeffer22weeks21uniprotmeropspaper
P1 pos Sources Proteases References
18 topfindascentschaeffer22weeks21 23264352 33536314 36313163 33526672
19 uniprot Signal peptidase
77 schaeffer22 36313163
109 merops MEP1B 21693781
209 paper 33796845
213 meropsschaeffer22uniprot FURIN , PCSK2 , PCSK4 , PCSK6 , PCSK5 , PCSK7 , furin and PCSK7 11481247 18505722 36313163
215 topfind 23264352
331 ascentschaeffer22weeks21 33536314 36313163 33526672
378 schaeffer22 36313163
387 schaeffer22 36313163
420 schaeffer22 36313163
621 paper 26554003
646 paperschaeffer22 33796845 36313163
655 paper 33796845

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Full JSON

Sequence

748 aa
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