HSA Human Sheddome Atlas
UniProt · Membrane protein

HBEGF (Proheparin-Binding EGF-Like Growth Factor)

Q99075 · 208 aa ·Signal peptide ·Propeptide · 1 predicted cleavages ·15 experimental cleavages

Cleavage peaks

Structure

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AlphaFold · pLDDT

Experimental cleavages

10 unique positions · 15 annotations · 3/10 (30%) covered by peaks
Sources (filter in the plot above): uniprotmerops+pmapmeropsschaeffer22
P1 pos Sources Proteases References
19 uniprot Signal peptidase
31 merops+pmap ADAM17 15066986
62 meropsschaeffer22uniprot FURIN|PCSK2|PCSK4|PCSK5|PCSK6|PCSK7 , ADAM17 , Or 72, or 73, or 76, or 81 18505722 15066986 36313159 1556128
72 merops ADAM17 15066986
73 merops ADAM17 15066986
148 uniprot Heparin-binding EGF-like growth factor
149 merops ADAM17 , MMP14 15066986 12135759
151 meropsmerops+pmap MMP14|MMP17 , MMP3 12135759 9395517
153 merops MMP17 12135759
208 uniprot C-terminal

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Sequence

208 aa
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