UniProt · Membrane protein

BACE1 (Beta-Secretase 1)

P56817 · 501 aa ·Signal peptide ·Propeptide ·1× TM · 1 predicted cleavages ·21 experimental cleavages

Cleavage peaks

Domain source Stringency Domain labels Peak lines Peak labels

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Colour: Topology pLDDT

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AlphaFold · pLDDT

8 unique positions · 21 annotations · 3/8 (38%) covered by peaks

Sources (filter in the plot above): uniprotmeropspmaphprd

P1 pos	Sources	Proteases	References
`21`	uniprot	Signal peptidase	—
`24`	merops	BACE1	10677483
`42`	merops	C11.001	11015226
`45`	meropspmapuniprot	BACE1 , KLK4 , FURIN , PCSK2 , PCSK4 , PCSK6 , PCSK5 , PCSK7	12204094 15389820 18505722 11481238 10887202 10956649 10591214
`46`	hprd	—	10887202
`57`	merops	C11.001	11015226
`99`	merops	BACE1	10677483
`184`	merops	BACE1	10677483

501 aa

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