{"uniprot":"Q9NZC2","gene":"TREM2","title":"TREM2 (Triggering Receptor Expressed on Myeloid Cells 2)","length":230,"sequence":["MEPLRLLILLFVTELSGAHNTTVFQGVAGQSLQVSCPYDSMKHWGRRKAWCRQLGEKGPCQRVVSTHNLWLLSFLRRWNGSTAITDDTLGGTLTITLRNLQPHDAGLYQCQSLHGSEADTLRKVLVEVLADPLDHRDAGDLWFPGESESFEDAHVEHSISRSLLEGEIPFPPTSILLLLACIFLIKILAASALWAAAWHGQKPGTHPPSELDCGHDPGYQLQTLPGLRDT"],"topology":[{"pos":1,"topology":"sp"},{"pos":2,"topology":"sp"},{"pos":3,"topology":"sp"},{"pos":4,"topology":"sp"},{"pos":5,"topology":"sp"},{"pos":6,"topology":"sp"},{"pos":7,"topology":"sp"},{"pos":8,"topology":"sp"},{"pos":9,"topology":"sp"},{"pos":10,"topology":"sp"},{"pos":11,"topology":"sp"},{"pos":12,"topology":"sp"},{"pos":13,"topology":"sp"},{"pos":14,"topology":"sp"},{"pos":15,"topology":"sp"},{"pos":16,"topology":"sp"},{"pos":17,"topology":"sp"},{"pos":18,"topology":"sp"},{"pos":19,"topology":"outside"},{"pos":20,"topology":"outside"},{"pos":21,"topology":"outside"},{"pos":22,"topology":"outside"},{"pos":23,"topology":"outside"},{"pos":24,"topology":"outside"},{"pos":25,"topology":"outside"},{"pos":26,"topology":"outside"},{"pos":27,"topology":"outside"},{"pos":28,"topology":"outside"},{"pos":29,"topology":"outside"},{"pos":30,"topology":"outside"},{"pos":31,"topology":"outside"},{"pos":32,"topology":"outside"},{"pos":33,"topology":"outside"},{"pos":34,"topology":"outside"},{"pos":35,"topology":"outside"},{"pos":36,"topology":"outside"},{"pos":37,"topology":"outside"},{"pos":38,"topology":"outside"},{"pos":39,"topology":"outside"},{"pos":40,"topology":"outside"},{"pos":41,"topology":"outside"},{"pos":42,"topology":"outside"},{"pos":43,"topology":"outside"},{"pos":44,"topology":"outside"},{"pos":45,"topology":"outside"},{"pos":46,"topology":"outside"},{"pos":47,"topology":"outside"},{"pos":48,"topology":"outside"},{"pos":49,"topology":"outside"},{"pos":50,"topology":"outside"},{"pos":51,"topology":"outside"},{"pos":52,"topology":"outside"},{"pos":53,"topology":"outside"},{"pos":54,"topology":"outside"},{"pos":55,"topology":"outside"},{"pos":56,"topology":"outside"},{"pos":57,"topology":"outside"},{"pos":58,"topology":"outside"},{"pos":59,"topology":"outside"},{"pos":60,"topology":"outside"},{"pos":61,"topology":"outside"},{"pos":62,"topology":"outside"},{"pos":63,"topology":"outside"},{"pos":64,"topology":"outside"},{"pos":65,"topology":"outside"},{"pos":66,"topology":"outside"},{"pos":67,"topology":"outside"},{"pos":68,"topology":"outside"},{"pos":69,"topology":"outside"},{"pos":70,"topology":"outside"},{"pos":71,"topology":"outside"},{"pos":72,"topology":"outside"},{"pos":73,"topology":"outside"},{"pos":74,"topology":"outside"},{"pos":75,"topology":"outside"},{"pos":76,"topology":"outside"},{"pos":77,"topology":"outside"},{"pos":78,"topology":"outside"},{"pos":79,"topology":"outside"},{"pos":80,"topology":"outside"},{"pos":81,"topology":"outside"},{"pos":82,"topology":"outside"},{"pos":83,"topology":"outside"},{"pos":84,"topology":"outside"},{"pos":85,"topology":"outside"},{"pos":86,"topology":"outside"},{"pos":87,"topology":"outside"},{"pos":88,"topology":"outside"},{"pos":89,"topology":"outside"},{"pos":90,"topology":"outside"},{"pos":91,"topology":"outside"},{"pos":92,"topology":"outside"},{"pos":93,"topology":"outside"},{"pos":94,"topology":"outside"},{"pos":95,"topology":"outside"},{"pos":96,"topology":"outside"},{"pos":97,"topology":"outside"},{"pos":98,"topology":"outside"},{"pos":99,"topology":"outside"},{"pos":100,"topology":"outside"},{"pos":101,"topology":"outside"},{"pos":102,"topology":"outside"},{"pos":103,"topology":"outside"},{"pos":104,"topology":"outside"},{"pos":105,"topology":"outside"},{"pos":106,"topology":"outside"},{"pos":107,"topology":"outside"},{"pos":108,"topology":"outside"},{"pos":109,"topology":"outside"},{"pos":110,"topology":"outside"},{"pos":111,"topology":"outside"},{"pos":112,"topology":"outside"},{"pos":113,"topology":"outside"},{"pos":114,"topology":"outside"},{"pos":115,"topology":"outside"},{"pos":116,"topology":"outside"},{"pos":117,"topology":"outside"},{"pos":118,"topology":"outside"},{"pos":119,"topology":"outside"},{"pos":120,"topology":"outside"},{"pos":121,"topology":"outside"},{"pos":122,"topology":"outside"},{"pos":123,"topology":"outside"},{"pos":124,"topology":"outside"},{"pos":125,"topology":"outside"},{"pos":126,"topology":"outside"},{"pos":127,"topology":"outside"},{"pos":128,"topology":"outside"},{"pos":129,"topology":"outside"},{"pos":130,"topology":"outside"},{"pos":131,"topology":"outside"},{"pos":132,"topology":"outside"},{"pos":133,"topology":"outside"},{"pos":134,"topology":"outside"},{"pos":135,"topology":"outside"},{"pos":136,"topology":"outside"},{"pos":137,"topology":"outside"},{"pos":138,"topology":"outside"},{"pos":139,"topology":"outside"},{"pos":140,"topology":"outside"},{"pos":141,"topology":"outside"},{"pos":142,"topology":"outside"},{"pos":143,"topology":"outside"},{"pos":144,"topology":"outside"},{"pos":145,"topology":"outside"},{"pos":146,"topology":"outside"},{"pos":147,"topology":"outside"},{"pos":148,"topology":"outside"},{"pos":149,"topology":"outside"},{"pos":150,"topology":"outside"},{"pos":151,"topology":"outside"},{"pos":152,"topology":"outside"},{"pos":153,"topology":"outside"},{"pos":154,"topology":"outside"},{"pos":155,"topology":"outside"},{"pos":156,"topology":"outside"},{"pos":157,"topology":"outside"},{"pos":158,"topology":"outside"},{"pos":159,"topology":"outside"},{"pos":160,"topology":"outside"},{"pos":161,"topology":"outside"},{"pos":162,"topology":"outside"},{"pos":163,"topology":"outside"},{"pos":164,"topology":"outside"},{"pos":165,"topology":"outside"},{"pos":166,"topology":"outside"},{"pos":167,"topology":"outside"},{"pos":168,"topology":"outside"},{"pos":169,"topology":"outside"},{"pos":170,"topology":"outside"},{"pos":171,"topology":"outside"},{"pos":172,"topology":"outside"},{"pos":173,"topology":"outside"},{"pos":174,"topology":"outside"},{"pos":175,"topology":"membr"},{"pos":176,"topology":"membr"},{"pos":177,"topology":"membr"},{"pos":178,"topology":"membr"},{"pos":179,"topology":"membr"},{"pos":180,"topology":"membr"},{"pos":181,"topology":"membr"},{"pos":182,"topology":"membr"},{"pos":183,"topology":"membr"},{"pos":184,"topology":"membr"},{"pos":185,"topology":"membr"},{"pos":186,"topology":"membr"},{"pos":187,"topology":"membr"},{"pos":188,"topology":"membr"},{"pos":189,"topology":"membr"},{"pos":190,"topology":"membr"},{"pos":191,"topology":"membr"},{"pos":192,"topology":"membr"},{"pos":193,"topology":"membr"},{"pos":194,"topology":"membr"},{"pos":195,"topology":"membr"},{"pos":196,"topology":"inside"},{"pos":197,"topology":"inside"},{"pos":198,"topology":"inside"},{"pos":199,"topology":"inside"},{"pos":200,"topology":"inside"},{"pos":201,"topology":"inside"},{"pos":202,"topology":"inside"},{"pos":203,"topology":"inside"},{"pos":204,"topology":"inside"},{"pos":205,"topology":"inside"},{"pos":206,"topology":"inside"},{"pos":207,"topology":"inside"},{"pos":208,"topology":"inside"},{"pos":209,"topology":"inside"},{"pos":210,"topology":"inside"},{"pos":211,"topology":"inside"},{"pos":212,"topology":"inside"},{"pos":213,"topology":"inside"},{"pos":214,"topology":"inside"},{"pos":215,"topology":"inside"},{"pos":216,"topology":"inside"},{"pos":217,"topology":"inside"},{"pos":218,"topology":"inside"},{"pos":219,"topology":"inside"},{"pos":220,"topology":"inside"},{"pos":221,"topology":"inside"},{"pos":222,"topology":"inside"},{"pos":223,"topology":"inside"},{"pos":224,"topology":"inside"},{"pos":225,"topology":"inside"},{"pos":226,"topology":"inside"},{"pos":227,"topology":"inside"},{"pos":228,"topology":"inside"},{"pos":229,"topology":"inside"},{"pos":230,"topology":"inside"}],"curves":{"stringent":[{"pos":1,"prob":0.000026},{"pos":2,"prob":0.000783},{"pos":3,"prob":0.00154},{"pos":4,"prob":0.060607},{"pos":5,"prob":0.119675},{"pos":6,"prob":0.501944},{"pos":7,"prob":0.884214},{"pos":8,"prob":0.925997},{"pos":9,"prob":0.96778},{"pos":10,"prob":0.982861},{"pos":11,"prob":0.997942},{"pos":12,"prob":0.998544},{"pos":13,"prob":0.999147},{"pos":14,"prob":0.998544},{"pos":15,"prob":0.997942},{"pos":16,"prob":0.997942},{"pos":17,"prob":0.997942},{"pos":18,"prob":0.997942},{"pos":19,"prob":0.997942},{"pos":20,"prob":0.997942},{"pos":21,"prob":0.993092},{"pos":22,"prob":0.371755},{"pos":23,"prob":0.027941},{"pos":24,"prob":0.001238},{"pos":25,"prob":0.000034},{"pos":26,"prob":0.000017},{"pos":27,"prob":7.782559e-06},{"pos":28,"prob":1.354361e-06},{"pos":29,"prob":7.690371e-07},{"pos":30,"prob":4.826531e-07},{"pos":31,"prob":4.192411e-07},{"pos":32,"prob":2.930987e-07},{"pos":33,"prob":2.403004e-07},{"pos":34,"prob":8.075836e-08},{"pos":35,"prob":2.718058e-08},{"pos":36,"prob":2.635749e-08},{"pos":37,"prob":1.77383e-08},{"pos":38,"prob":4.171013e-09},{"pos":39,"prob":4.977262e-10},{"pos":40,"prob":4.16853e-10},{"pos":41,"prob":3.860536e-10},{"pos":42,"prob":9.555149e-11},{"pos":43,"prob":3.979465e-11},{"pos":44,"prob":2.722298e-11},{"pos":45,"prob":2.036389e-11},{"pos":46,"prob":1.298329e-11},{"pos":47,"prob":1.2193e-11},{"pos":48,"prob":9.95585e-12},{"pos":49,"prob":8.574722e-12},{"pos":50,"prob":6.922823e-12},{"pos":51,"prob":5.711876e-12},{"pos":52,"prob":6.922823e-12},{"pos":53,"prob":8.574722e-12},{"pos":54,"prob":6.922823e-12},{"pos":55,"prob":5.711876e-12},{"pos":56,"prob":5.711876e-12},{"pos":57,"prob":6.922823e-12},{"pos":58,"prob":8.574722e-12},{"pos":59,"prob":8.574722e-12},{"pos":60,"prob":8.574722e-12},{"pos":61,"prob":1.176599e-11},{"pos":62,"prob":1.346058e-11},{"pos":63,"prob":4.679299e-11},{"pos":64,"prob":1.371257e-10},{"pos":65,"prob":2.128201e-09},{"pos":66,"prob":5.218149e-09},{"pos":67,"prob":2.053064e-08},{"pos":68,"prob":2.458447e-08},{"pos":69,"prob":2.671411e-08},{"pos":70,"prob":2.671411e-08},{"pos":71,"prob":2.671411e-08},{"pos":72,"prob":2.671411e-08},{"pos":73,"prob":2.671411e-08},{"pos":74,"prob":2.671411e-08},{"pos":75,"prob":2.458447e-08},{"pos":76,"prob":2.053064e-08},{"pos":77,"prob":1.892335e-08},{"pos":78,"prob":7.608424e-09},{"pos":79,"prob":3.05077e-09},{"pos":80,"prob":2.154922e-09},{"pos":81,"prob":1.952984e-09},{"pos":82,"prob":1.237727e-09},{"pos":83,"prob":7.291395e-10},{"pos":84,"prob":3.248616e-10},{"pos":85,"prob":3.248616e-10},{"pos":86,"prob":3.248616e-10},{"pos":87,"prob":3.248616e-10},{"pos":88,"prob":3.081611e-10},{"pos":89,"prob":3.081611e-10},{"pos":90,"prob":3.248616e-10},{"pos":91,"prob":3.942644e-10},{"pos":92,"prob":5.909248e-10},{"pos":93,"prob":5.909248e-10},{"pos":94,"prob":5.909248e-10},{"pos":95,"prob":5.909248e-10},{"pos":96,"prob":8.274109e-10},{"pos":97,"prob":1.682634e-09},{"pos":98,"prob":1.692596e-09},{"pos":99,"prob":1.692596e-09},{"pos":100,"prob":1.692596e-09},{"pos":101,"prob":1.692596e-09},{"pos":102,"prob":1.682634e-09},{"pos":103,"prob":1.692596e-09},{"pos":104,"prob":1.935466e-09},{"pos":105,"prob":2.99235e-09},{"pos":106,"prob":3.069792e-09},{"pos":107,"prob":3.069792e-09},{"pos":108,"prob":3.454661e-09},{"pos":109,"prob":3.454661e-09},{"pos":110,"prob":3.908906e-09},{"pos":111,"prob":4.035043e-09},{"pos":112,"prob":4.063573e-09},{"pos":113,"prob":4.082684e-09},{"pos":114,"prob":1.219004e-08},{"pos":115,"prob":4.715637e-08},{"pos":116,"prob":2.998348e-07},{"pos":117,"prob":5.331823e-07},{"pos":118,"prob":1.305146e-06},{"pos":119,"prob":8.094901e-06},{"pos":120,"prob":0.000288},{"pos":121,"prob":0.00861},{"pos":122,"prob":0.025664},{"pos":123,"prob":0.035382},{"pos":124,"prob":0.037841},{"pos":125,"prob":0.074531},{"pos":126,"prob":0.092016},{"pos":127,"prob":0.092016},{"pos":128,"prob":0.092016},{"pos":129,"prob":0.092016},{"pos":130,"prob":0.092016},{"pos":131,"prob":0.092016},{"pos":132,"prob":0.074531},{"pos":133,"prob":0.035382},{"pos":134,"prob":0.02525},{"pos":135,"prob":0.002316},{"pos":136,"prob":0.001165},{"pos":137,"prob":0.001014},{"pos":138,"prob":0.000983},{"pos":139,"prob":0.000983},{"pos":140,"prob":0.000983},{"pos":141,"prob":0.000983},{"pos":142,"prob":0.000983},{"pos":143,"prob":0.000983},{"pos":144,"prob":0.000983},{"pos":145,"prob":0.000983},{"pos":146,"prob":0.003249},{"pos":147,"prob":0.005573},{"pos":148,"prob":0.009117},{"pos":149,"prob":0.051827},{"pos":150,"prob":0.103952},{"pos":151,"prob":0.364278},{"pos":152,"prob":0.392981},{"pos":153,"prob":0.650194},{"pos":154,"prob":0.772216},{"pos":155,"prob":0.896261},{"pos":156,"prob":0.960582},{"pos":157,"prob":0.960582},{"pos":158,"prob":0.960582},{"pos":159,"prob":0.960582},{"pos":160,"prob":0.960582},{"pos":161,"prob":0.960582},{"pos":162,"prob":0.960582},{"pos":163,"prob":0.960582},{"pos":164,"prob":0.827734},{"pos":165,"prob":0.325882},{"pos":166,"prob":0.036016},{"pos":167,"prob":0.006237},{"pos":168,"prob":0.001072},{"pos":169,"prob":0.000236},{"pos":170,"prob":0.000023},{"pos":171,"prob":8.174504e-06},{"pos":172,"prob":2.959789e-06},{"pos":173,"prob":1.10953e-06},{"pos":174,"prob":8.223508e-07},{"pos":175,"prob":3.045972e-07},{"pos":176,"prob":1.51788e-08},{"pos":177,"prob":9.558494e-09},{"pos":178,"prob":4.510818e-09},{"pos":179,"prob":1.479051e-09},{"pos":180,"prob":1.370787e-09},{"pos":181,"prob":1.289239e-09},{"pos":182,"prob":7.640238e-10},{"pos":183,"prob":7.539598e-10},{"pos":184,"prob":6.127289e-10},{"pos":185,"prob":3.285374e-10},{"pos":186,"prob":2.204106e-10},{"pos":187,"prob":2.204106e-10},{"pos":188,"prob":2.204106e-10},{"pos":189,"prob":3.285374e-10},{"pos":190,"prob":6.47845e-10},{"pos":191,"prob":7.539598e-10},{"pos":192,"prob":7.539598e-10},{"pos":193,"prob":7.539598e-10},{"pos":194,"prob":7.539598e-10},{"pos":195,"prob":1.029221e-09},{"pos":196,"prob":8.494807e-09},{"pos":197,"prob":2.725025e-08},{"pos":198,"prob":8.702332e-08},{"pos":199,"prob":1.022105e-07},{"pos":200,"prob":3.381153e-07},{"pos":201,"prob":1.227643e-06},{"pos":202,"prob":2.472113e-06},{"pos":203,"prob":2.473601e-06},{"pos":204,"prob":3.035329e-06},{"pos":205,"prob":3.580168e-06},{"pos":206,"prob":4.301717e-06},{"pos":207,"prob":4.301717e-06},{"pos":208,"prob":4.301717e-06},{"pos":209,"prob":4.301717e-06},{"pos":210,"prob":4.301717e-06},{"pos":211,"prob":4.301717e-06},{"pos":212,"prob":4.301717e-06},{"pos":213,"prob":4.301717e-06},{"pos":214,"prob":4.121501e-06},{"pos":215,"prob":4.121501e-06},{"pos":216,"prob":3.832068e-06},{"pos":217,"prob":3.542635e-06},{"pos":218,"prob":3.220975e-06},{"pos":219,"prob":2.899316e-06},{"pos":220,"prob":2.754265e-06},{"pos":221,"prob":2.609215e-06},{"pos":222,"prob":2.575323e-06},{"pos":223,"prob":2.609215e-06},{"pos":224,"prob":2.754265e-06},{"pos":225,"prob":2.899316e-06},{"pos":226,"prob":3.510408e-06},{"pos":227,"prob":4.121501e-06},{"pos":228,"prob":7.604907e-06},{"pos":229,"prob":0.000011}],"moderate":[{"pos":1,"prob":0.000026},{"pos":2,"prob":0.000783},{"pos":3,"prob":0.00154},{"pos":4,"prob":0.060607},{"pos":5,"prob":0.119675},{"pos":6,"prob":0.501944},{"pos":7,"prob":0.884214},{"pos":8,"prob":0.925997},{"pos":9,"prob":0.96778},{"pos":10,"prob":0.982861},{"pos":11,"prob":0.997942},{"pos":12,"prob":0.998544},{"pos":13,"prob":0.999147},{"pos":14,"prob":0.998544},{"pos":15,"prob":0.997942},{"pos":16,"prob":0.997942},{"pos":17,"prob":0.997942},{"pos":18,"prob":0.997942},{"pos":19,"prob":0.997942},{"pos":20,"prob":0.997942},{"pos":21,"prob":0.993092},{"pos":22,"prob":0.371755},{"pos":23,"prob":0.027941},{"pos":24,"prob":0.001238},{"pos":25,"prob":0.000034},{"pos":26,"prob":0.000017},{"pos":27,"prob":7.782559e-06},{"pos":28,"prob":1.354361e-06},{"pos":29,"prob":7.690371e-07},{"pos":30,"prob":4.826531e-07},{"pos":31,"prob":4.192411e-07},{"pos":32,"prob":2.930987e-07},{"pos":33,"prob":2.403004e-07},{"pos":34,"prob":8.075836e-08},{"pos":35,"prob":2.718058e-08},{"pos":36,"prob":2.635749e-08},{"pos":37,"prob":1.77383e-08},{"pos":38,"prob":4.171013e-09},{"pos":39,"prob":4.977262e-10},{"pos":40,"prob":4.16853e-10},{"pos":41,"prob":3.860536e-10},{"pos":42,"prob":9.555149e-11},{"pos":43,"prob":3.979465e-11},{"pos":44,"prob":2.722298e-11},{"pos":45,"prob":2.036389e-11},{"pos":46,"prob":1.298329e-11},{"pos":47,"prob":1.2193e-11},{"pos":48,"prob":9.95585e-12},{"pos":49,"prob":8.574722e-12},{"pos":50,"prob":6.922823e-12},{"pos":51,"prob":5.711876e-12},{"pos":52,"prob":6.922823e-12},{"pos":53,"prob":8.574722e-12},{"pos":54,"prob":6.922823e-12},{"pos":55,"prob":5.711876e-12},{"pos":56,"prob":5.711876e-12},{"pos":57,"prob":6.922823e-12},{"pos":58,"prob":8.574722e-12},{"pos":59,"prob":8.574722e-12},{"pos":60,"prob":8.574722e-12},{"pos":61,"prob":1.176599e-11},{"pos":62,"prob":1.346058e-11},{"pos":63,"prob":4.679299e-11},{"pos":64,"prob":1.371257e-10},{"pos":65,"prob":2.128201e-09},{"pos":66,"prob":5.218149e-09},{"pos":67,"prob":2.053064e-08},{"pos":68,"prob":2.458447e-08},{"pos":69,"prob":2.671411e-08},{"pos":70,"prob":2.671411e-08},{"pos":71,"prob":2.671411e-08},{"pos":72,"prob":2.671411e-08},{"pos":73,"prob":2.671411e-08},{"pos":74,"prob":2.671411e-08},{"pos":75,"prob":2.458447e-08},{"pos":76,"prob":2.053064e-08},{"pos":77,"prob":1.892335e-08},{"pos":78,"prob":7.608424e-09},{"pos":79,"prob":3.05077e-09},{"pos":80,"prob":2.154922e-09},{"pos":81,"prob":1.952984e-09},{"pos":82,"prob":1.237727e-09},{"pos":83,"prob":7.291395e-10},{"pos":84,"prob":3.248616e-10},{"pos":85,"prob":3.248616e-10},{"pos":86,"prob":3.248616e-10},{"pos":87,"prob":3.248616e-10},{"pos":88,"prob":3.081611e-10},{"pos":89,"prob":3.081611e-10},{"pos":90,"prob":3.248616e-10},{"pos":91,"prob":3.942644e-10},{"pos":92,"prob":5.909248e-10},{"pos":93,"prob":5.909248e-10},{"pos":94,"prob":5.909248e-10},{"pos":95,"prob":5.909248e-10},{"pos":96,"prob":8.274109e-10},{"pos":97,"prob":1.682634e-09},{"pos":98,"prob":1.692596e-09},{"pos":99,"prob":1.692596e-09},{"pos":100,"prob":1.692596e-09},{"pos":101,"prob":1.692596e-09},{"pos":102,"prob":1.682634e-09},{"pos":103,"prob":1.692596e-09},{"pos":104,"prob":1.935466e-09},{"pos":105,"prob":2.99235e-09},{"pos":106,"prob":3.069792e-09},{"pos":107,"prob":3.069792e-09},{"pos":108,"prob":3.454661e-09},{"pos":109,"prob":3.454661e-09},{"pos":110,"prob":3.908906e-09},{"pos":111,"prob":4.035043e-09},{"pos":112,"prob":4.063573e-09},{"pos":113,"prob":4.082684e-09},{"pos":114,"prob":1.219004e-08},{"pos":115,"prob":4.715637e-08},{"pos":116,"prob":2.998348e-07},{"pos":117,"prob":5.331823e-07},{"pos":118,"prob":1.305146e-06},{"pos":119,"prob":8.094901e-06},{"pos":120,"prob":0.000288},{"pos":121,"prob":0.00861},{"pos":122,"prob":0.025664},{"pos":123,"prob":0.035382},{"pos":124,"prob":0.037841},{"pos":125,"prob":0.074531},{"pos":126,"prob":0.092016},{"pos":127,"prob":0.092016},{"pos":128,"prob":0.092016},{"pos":129,"prob":0.092016},{"pos":130,"prob":0.092016},{"pos":131,"prob":0.092016},{"pos":132,"prob":0.074531},{"pos":133,"prob":0.035382},{"pos":134,"prob":0.02525},{"pos":135,"prob":0.002316},{"pos":136,"prob":0.001165},{"pos":137,"prob":0.001014},{"pos":138,"prob":0.000983},{"pos":139,"prob":0.000983},{"pos":140,"prob":0.000983},{"pos":141,"prob":0.000983},{"pos":142,"prob":0.000983},{"pos":143,"prob":0.000983},{"pos":144,"prob":0.000983},{"pos":145,"prob":0.000983},{"pos":146,"prob":0.003249},{"pos":147,"prob":0.005573},{"pos":148,"prob":0.009117},{"pos":149,"prob":0.051827},{"pos":150,"prob":0.103952},{"pos":151,"prob":0.364278},{"pos":152,"prob":0.392981},{"pos":153,"prob":0.650194},{"pos":154,"prob":0.772216},{"pos":155,"prob":0.896261},{"pos":156,"prob":0.960582},{"pos":157,"prob":0.960582},{"pos":158,"prob":0.960582},{"pos":159,"prob":0.960582},{"pos":160,"prob":0.960582},{"pos":161,"prob":0.960582},{"pos":162,"prob":0.960582},{"pos":163,"prob":0.960582},{"pos":164,"prob":0.827734},{"pos":165,"prob":0.325882},{"pos":166,"prob":0.036016},{"pos":167,"prob":0.006237},{"pos":168,"prob":0.001072},{"pos":169,"prob":0.000236},{"pos":170,"prob":0.000023},{"pos":171,"prob":8.174504e-06},{"pos":172,"prob":2.959789e-06},{"pos":173,"prob":1.10953e-06},{"pos":174,"prob":8.223508e-07},{"pos":175,"prob":3.045972e-07},{"pos":176,"prob":1.51788e-08},{"pos":177,"prob":9.558494e-09},{"pos":178,"prob":4.510818e-09},{"pos":179,"prob":1.479051e-09},{"pos":180,"prob":1.370787e-09},{"pos":181,"prob":1.289239e-09},{"pos":182,"prob":7.640238e-10},{"pos":183,"prob":7.539598e-10},{"pos":184,"prob":6.127289e-10},{"pos":185,"prob":3.285374e-10},{"pos":186,"prob":2.204106e-10},{"pos":187,"prob":2.204106e-10},{"pos":188,"prob":2.204106e-10},{"pos":189,"prob":3.285374e-10},{"pos":190,"prob":6.47845e-10},{"pos":191,"prob":7.539598e-10},{"pos":192,"prob":7.539598e-10},{"pos":193,"prob":7.539598e-10},{"pos":194,"prob":7.539598e-10},{"pos":195,"prob":1.029221e-09},{"pos":196,"prob":8.494807e-09},{"pos":197,"prob":2.725025e-08},{"pos":198,"prob":8.702332e-08},{"pos":199,"prob":1.022105e-07},{"pos":200,"prob":3.381153e-07},{"pos":201,"prob":1.227643e-06},{"pos":202,"prob":2.472113e-06},{"pos":203,"prob":2.473601e-06},{"pos":204,"prob":3.035329e-06},{"pos":205,"prob":3.580168e-06},{"pos":206,"prob":4.301717e-06},{"pos":207,"prob":4.301717e-06},{"pos":208,"prob":4.301717e-06},{"pos":209,"prob":4.301717e-06},{"pos":210,"prob":4.301717e-06},{"pos":211,"prob":4.301717e-06},{"pos":212,"prob":4.301717e-06},{"pos":213,"prob":4.301717e-06},{"pos":214,"prob":4.121501e-06},{"pos":215,"prob":4.121501e-06},{"pos":216,"prob":3.832068e-06},{"pos":217,"prob":3.542635e-06},{"pos":218,"prob":3.220975e-06},{"pos":219,"prob":2.899316e-06},{"pos":220,"prob":2.754265e-06},{"pos":221,"prob":2.609215e-06},{"pos":222,"prob":2.575323e-06},{"pos":223,"prob":2.609215e-06},{"pos":224,"prob":2.754265e-06},{"pos":225,"prob":2.899316e-06},{"pos":226,"prob":3.510408e-06},{"pos":227,"prob":4.121501e-06},{"pos":228,"prob":7.604907e-06},{"pos":229,"prob":0.000011}],"permissive":[{"pos":1,"prob":0.000026},{"pos":2,"prob":0.000783},{"pos":3,"prob":0.00154},{"pos":4,"prob":0.060607},{"pos":5,"prob":0.119675},{"pos":6,"prob":0.501944},{"pos":7,"prob":0.884214},{"pos":8,"prob":0.925997},{"pos":9,"prob":0.96778},{"pos":10,"prob":0.982861},{"pos":11,"prob":0.997942},{"pos":12,"prob":0.998544},{"pos":13,"prob":0.999147},{"pos":14,"prob":0.998544},{"pos":15,"prob":0.997942},{"pos":16,"prob":0.997942},{"pos":17,"prob":0.997942},{"pos":18,"prob":0.997942},{"pos":19,"prob":0.997942},{"pos":20,"prob":0.997942},{"pos":21,"prob":0.993092},{"pos":22,"prob":0.371755},{"pos":23,"prob":0.027941},{"pos":24,"prob":0.001238},{"pos":25,"prob":0.000034},{"pos":26,"prob":0.000017},{"pos":27,"prob":7.782559e-06},{"pos":28,"prob":1.354361e-06},{"pos":29,"prob":7.690371e-07},{"pos":30,"prob":4.826531e-07},{"pos":31,"prob":4.192411e-07},{"pos":32,"prob":2.930987e-07},{"pos":33,"prob":2.403004e-07},{"pos":34,"prob":8.075836e-08},{"pos":35,"prob":2.718058e-08},{"pos":36,"prob":2.635749e-08},{"pos":37,"prob":1.77383e-08},{"pos":38,"prob":4.171013e-09},{"pos":39,"prob":4.977262e-10},{"pos":40,"prob":4.16853e-10},{"pos":41,"prob":3.860536e-10},{"pos":42,"prob":9.555149e-11},{"pos":43,"prob":3.979465e-11},{"pos":44,"prob":2.722298e-11},{"pos":45,"prob":2.036389e-11},{"pos":46,"prob":1.298329e-11},{"pos":47,"prob":1.2193e-11},{"pos":48,"prob":9.95585e-12},{"pos":49,"prob":8.574722e-12},{"pos":50,"prob":6.922823e-12},{"pos":51,"prob":5.711876e-12},{"pos":52,"prob":6.922823e-12},{"pos":53,"prob":8.574722e-12},{"pos":54,"prob":6.922823e-12},{"pos":55,"prob":5.711876e-12},{"pos":56,"prob":5.711876e-12},{"pos":57,"prob":6.922823e-12},{"pos":58,"prob":8.574722e-12},{"pos":59,"prob":8.574722e-12},{"pos":60,"prob":8.574722e-12},{"pos":61,"prob":1.176599e-11},{"pos":62,"prob":1.346058e-11},{"pos":63,"prob":4.679299e-11},{"pos":64,"prob":1.371257e-10},{"pos":65,"prob":2.128201e-09},{"pos":66,"prob":5.218149e-09},{"pos":67,"prob":2.053064e-08},{"pos":68,"prob":2.458447e-08},{"pos":69,"prob":2.671411e-08},{"pos":70,"prob":2.671411e-08},{"pos":71,"prob":2.671411e-08},{"pos":72,"prob":2.671411e-08},{"pos":73,"prob":2.671411e-08},{"pos":74,"prob":2.671411e-08},{"pos":75,"prob":2.458447e-08},{"pos":76,"prob":2.053064e-08},{"pos":77,"prob":1.892335e-08},{"pos":78,"prob":7.608424e-09},{"pos":79,"prob":3.05077e-09},{"pos":80,"prob":2.154922e-09},{"pos":81,"prob":1.952984e-09},{"pos":82,"prob":1.237727e-09},{"pos":83,"prob":7.291395e-10},{"pos":84,"prob":3.248616e-10},{"pos":85,"prob":3.248616e-10},{"pos":86,"prob":3.248616e-10},{"pos":87,"prob":3.248616e-10},{"pos":88,"prob":3.081611e-10},{"pos":89,"prob":3.081611e-10},{"pos":90,"prob":3.248616e-10},{"pos":91,"prob":3.942644e-10},{"pos":92,"prob":5.909248e-10},{"pos":93,"prob":5.909248e-10},{"pos":94,"prob":5.909248e-10},{"pos":95,"prob":5.909248e-10},{"pos":96,"prob":8.274109e-10},{"pos":97,"prob":1.682634e-09},{"pos":98,"prob":1.692596e-09},{"pos":99,"prob":1.692596e-09},{"pos":100,"prob":1.692596e-09},{"pos":101,"prob":1.692596e-09},{"pos":102,"prob":1.682634e-09},{"pos":103,"prob":1.692596e-09},{"pos":104,"prob":1.935466e-09},{"pos":105,"prob":2.99235e-09},{"pos":106,"prob":3.069792e-09},{"pos":107,"prob":3.069792e-09},{"pos":108,"prob":3.454661e-09},{"pos":109,"prob":3.454661e-09},{"pos":110,"prob":3.908906e-09},{"pos":111,"prob":4.035043e-09},{"pos":112,"prob":4.063573e-09},{"pos":113,"prob":4.082684e-09},{"pos":114,"prob":1.219004e-08},{"pos":115,"prob":4.715637e-08},{"pos":116,"prob":2.998348e-07},{"pos":117,"prob":5.331823e-07},{"pos":118,"prob":1.305146e-06},{"pos":119,"prob":8.094901e-06},{"pos":120,"prob":0.000288},{"pos":121,"prob":0.00861},{"pos":122,"prob":0.025664},{"pos":123,"prob":0.035382},{"pos":124,"prob":0.037841},{"pos":125,"prob":0.074531},{"pos":126,"prob":0.092016},{"pos":127,"prob":0.092016},{"pos":128,"prob":0.092016},{"pos":129,"prob":0.092016},{"pos":130,"prob":0.092016},{"pos":131,"prob":0.092016},{"pos":132,"prob":0.074531},{"pos":133,"prob":0.035382},{"pos":134,"prob":0.02525},{"pos":135,"prob":0.002316},{"pos":136,"prob":0.001165},{"pos":137,"prob":0.001014},{"pos":138,"prob":0.000983},{"pos":139,"prob":0.000983},{"pos":140,"prob":0.000983},{"pos":141,"prob":0.000983},{"pos":142,"prob":0.000983},{"pos":143,"prob":0.000983},{"pos":144,"prob":0.000983},{"pos":145,"prob":0.000983},{"pos":146,"prob":0.003249},{"pos":147,"prob":0.005573},{"pos":148,"prob":0.009117},{"pos":149,"prob":0.051827},{"pos":150,"prob":0.103952},{"pos":151,"prob":0.364278},{"pos":152,"prob":0.392981},{"pos":153,"prob":0.650194},{"pos":154,"prob":0.772216},{"pos":155,"prob":0.896261},{"pos":156,"prob":0.960582},{"pos":157,"prob":0.960582},{"pos":158,"prob":0.960582},{"pos":159,"prob":0.960582},{"pos":160,"prob":0.960582},{"pos":161,"prob":0.960582},{"pos":162,"prob":0.960582},{"pos":163,"prob":0.960582},{"pos":164,"prob":0.827734},{"pos":165,"prob":0.325882},{"pos":166,"prob":0.036016},{"pos":167,"prob":0.006237},{"pos":168,"prob":0.001072},{"pos":169,"prob":0.000236},{"pos":170,"prob":0.000023},{"pos":171,"prob":8.174504e-06},{"pos":172,"prob":2.959789e-06},{"pos":173,"prob":1.10953e-06},{"pos":174,"prob":8.223508e-07},{"pos":175,"prob":3.045972e-07},{"pos":176,"prob":1.51788e-08},{"pos":177,"prob":9.558494e-09},{"pos":178,"prob":4.510818e-09},{"pos":179,"prob":1.479051e-09},{"pos":180,"prob":1.370787e-09},{"pos":181,"prob":1.289239e-09},{"pos":182,"prob":7.640238e-10},{"pos":183,"prob":7.539598e-10},{"pos":184,"prob":6.127289e-10},{"pos":185,"prob":3.285374e-10},{"pos":186,"prob":2.204106e-10},{"pos":187,"prob":2.204106e-10},{"pos":188,"prob":2.204106e-10},{"pos":189,"prob":3.285374e-10},{"pos":190,"prob":6.47845e-10},{"pos":191,"prob":7.539598e-10},{"pos":192,"prob":7.539598e-10},{"pos":193,"prob":7.539598e-10},{"pos":194,"prob":7.539598e-10},{"pos":195,"prob":1.029221e-09},{"pos":196,"prob":8.494807e-09},{"pos":197,"prob":2.725025e-08},{"pos":198,"prob":8.702332e-08},{"pos":199,"prob":1.022105e-07},{"pos":200,"prob":3.381153e-07},{"pos":201,"prob":1.227643e-06},{"pos":202,"prob":2.472113e-06},{"pos":203,"prob":2.473601e-06},{"pos":204,"prob":3.035329e-06},{"pos":205,"prob":3.580168e-06},{"pos":206,"prob":4.301717e-06},{"pos":207,"prob":4.301717e-06},{"pos":208,"prob":4.301717e-06},{"pos":209,"prob":4.301717e-06},{"pos":210,"prob":4.301717e-06},{"pos":211,"prob":4.301717e-06},{"pos":212,"prob":4.301717e-06},{"pos":213,"prob":4.301717e-06},{"pos":214,"prob":4.121501e-06},{"pos":215,"prob":4.121501e-06},{"pos":216,"prob":3.832068e-06},{"pos":217,"prob":3.542635e-06},{"pos":218,"prob":3.220975e-06},{"pos":219,"prob":2.899316e-06},{"pos":220,"prob":2.754265e-06},{"pos":221,"prob":2.609215e-06},{"pos":222,"prob":2.575323e-06},{"pos":223,"prob":2.609215e-06},{"pos":224,"prob":2.754265e-06},{"pos":225,"prob":2.899316e-06},{"pos":226,"prob":3.510408e-06},{"pos":227,"prob":4.121501e-06},{"pos":228,"prob":7.604907e-06},{"pos":229,"prob":0.000011}]},"peaks":{"stringent":[{"peak_position":15,"peak_height":0.997646,"prominence":0.97665,"width":15.760068,"left_ip":5.07289,"right_ip":20.832957,"left_ip_0.9":2.25667,"right_ip_0.9":23.393547,"left_ip_0.75":3.550868,"right_ip_0.75":22.206702,"left_ip_1.0":9.348091e-16,"right_ip_1.0":25.14606,"octamer":"VTEL|SGAH"},{"peak_position":128,"peak_height":0.087574,"prominence":0.086536,"width":9.603241,"left_ip":122.484996,"right_ip":132.088237,"left_ip_0.9":119.110615,"right_ip_0.9":134.972121,"left_ip_0.75":120.674845,"right_ip_0.75":133.623468,"left_ip_1.0":116.403299,"right_ip_1.0":140,"octamer":"LVEV|LADP"},{"peak_position":159,"peak_height":0.953181,"prominence":0.953181,"width":12.644979,"left_ip":151.112331,"right_ip":163.75731,"left_ip_0.9":147.467723,"right_ip_0.9":166.547396,"left_ip_0.75":149.190111,"right_ip_0.75":165.210622,"left_ip_1.0":87.159287,"right_ip_1.0":185.999999,"octamer":"EHSI|SRSL"}],"moderate":[{"peak_position":15,"peak_height":0.997646,"prominence":0.97665,"width":15.760068,"left_ip":5.07289,"right_ip":20.832957,"left_ip_0.9":2.25667,"right_ip_0.9":23.393547,"left_ip_0.75":3.550868,"right_ip_0.75":22.206702,"left_ip_1.0":9.348091e-16,"right_ip_1.0":25.14606,"octamer":"VTEL|SGAH"},{"peak_position":128,"peak_height":0.087574,"prominence":0.086536,"width":9.603241,"left_ip":122.484996,"right_ip":132.088237,"left_ip_0.9":119.110615,"right_ip_0.9":134.972121,"left_ip_0.75":120.674845,"right_ip_0.75":133.623468,"left_ip_1.0":116.403299,"right_ip_1.0":140,"octamer":"LVEV|LADP"},{"peak_position":159,"peak_height":0.953181,"prominence":0.953181,"width":12.644979,"left_ip":151.112331,"right_ip":163.75731,"left_ip_0.9":147.467723,"right_ip_0.9":166.547396,"left_ip_0.75":149.190111,"right_ip_0.75":165.210622,"left_ip_1.0":87.159287,"right_ip_1.0":185.999999,"octamer":"EHSI|SRSL"}],"permissive":[{"peak_position":15,"peak_height":0.997646,"prominence":0.97665,"width":15.760068,"left_ip":5.07289,"right_ip":20.832957,"left_ip_0.9":2.25667,"right_ip_0.9":23.393547,"left_ip_0.75":3.550868,"right_ip_0.75":22.206702,"left_ip_1.0":9.348091e-16,"right_ip_1.0":25.14606,"octamer":"VTEL|SGAH"},{"peak_position":128,"peak_height":0.087574,"prominence":0.086536,"width":9.603241,"left_ip":122.484996,"right_ip":132.088237,"left_ip_0.9":119.110615,"right_ip_0.9":134.972121,"left_ip_0.75":120.674845,"right_ip_0.75":133.623468,"left_ip_1.0":116.403299,"right_ip_1.0":140,"octamer":"LVEV|LADP"},{"peak_position":159,"peak_height":0.953181,"prominence":0.953181,"width":12.644979,"left_ip":151.112331,"right_ip":163.75731,"left_ip_0.9":147.467723,"right_ip_0.9":166.547396,"left_ip_0.75":149.190111,"right_ip_0.75":165.210622,"left_ip_1.0":87.159287,"right_ip_1.0":185.999999,"octamer":"EHSI|SRSL"}]},"domains":{"uniprot":[{"start":29,"end":112,"name":"Ig-like V-type"}],"ted":[{"start":17,"end":132,"name":"medium"}],"pfam":[{"start":23,"end":128,"name":"Immunoglobulin V-set domain"}],"gene3d":[{"start":19,"end":130,"name":"Immunoglobulin-like fold"}],"superfamily":[{"start":26,"end":116,"name":"Immunoglobulin-like domain superfamily"}]},"cleavages":[{"pos":18,"pos_p1":18,"source":"uniprot","citation":"","pmid":"","doi":"","protease":"","protease_uniprot":"","uniprot_feature_type":"signal_peptide","uniprot_description":"Signal peptidase","merops_protease_code":"","merops_cleavage_type":"","merops_method":"","topfind_method":"","weeks_method":"","schaeffer_cell_types":""},{"pos":157,"pos_p1":157,"source":"uniprot","citation":"Schlepckow_2017_EMBOMolMed","pmid":"28855300|28855301|28923481","doi":"","protease":"","protease_uniprot":"","uniprot_feature_type":"cleavage_site","uniprot_description":"Cleavage of ectodomain","merops_protease_code":"","merops_cleavage_type":"","merops_method":"","topfind_method":"","weeks_method":"","schaeffer_cell_types":""}]}